蒽醌类似物的合成及其生物活性研究进展

发布时间：2018-04-13 16:36

本文选题：蒽醌类化合物 + 金属配合物　；参考：《中国药房》2015年25期

【摘要】：目的:综述蒽醌类似物的合成及其生物活性研究进展,为合成具有新颖结构和生物活性的蒽醌类似物提供理论依据。方法:利用逆查法、循环法等文献检索方法,以"Anthraquinone""蒽醌""合成""生物活性"等为关键词,查询2004-2014年美国《化学文摘》(网络版)、中国知网等数据库中与蒽醌类似物合成修饰、生物活性研究相关的文献,对其合成修饰的主要方法及生物活性进行综述。结果:共检索到相关文献60余条,其中有效文献29条。常通过4种途径合成蒽醌类似物,即以蒽醌为前体,共轭母核中引入卤素原子、含氮基团、阳离子等取代基;利用傅-克反应合环制备β-取代化合物;与金属离子配合形成配合物;利用狄尔斯-阿尔德反应等方法合成具有特殊光物理、光化学性质的蒽醌类似物。蒽醌类似物主要具有抗菌和抗肿瘤活性。结论:蒽醌类化合物是一种潜在的抗肿瘤分子,对其结构进行优化,可为筛选出高效的抗肿瘤药物提供一定的参考依据。
[Abstract]:Aim: to review the synthesis and bioactivity of anthraquinone analogues and to provide theoretical basis for the synthesis of anthraquinone analogues with novel structures and biological activities.Methods: by means of reverse search, circular method and other literature retrieval methods, using "Anthraquinone", "anthraquinone" synthesis, "biological activity" and so on as keywords, we inquired about the synthesis and modification of anthraquinone analogues in American Chemical Abstracts from 2004 to 2014.The main methods of synthesis and modification of bioactivity and its bioactivity were reviewed.Results: more than 60 literatures were retrieved, 29 of which were valid.The anthraquinone analogue was synthesized by four ways, namely, using anthraquinone as precursor, introducing halogen atoms, nitrogen-containing groups, cationic substituents into conjugated parent nuclei, and synthesizing 尾 -substituted compounds by Friedel-gram reaction ring.The anthraquinone analogue with special photophysical and photochemical properties was synthesized by Dils-Alder reaction.Anthraquinone analogue mainly has antibacterial and anti-tumor activity.Conclusion: anthraquinone is a potential antitumor molecule. The structure of anthraquinone can be used as a reference for the screening of effective antitumor drugs.
【作者单位】：云南中医学院药学院;
【基金】：云南省应用基础研究计划项目(No.2012FB169;2014FZ091)
【分类号】：R914.5;R96

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