模糊综合评价法在处方筛选中的应用研究

发布时间：2018-04-13 23:40

本文选题：模糊综合评价法 + 复方氨酚那敏颗粒　；参考：《中国药房》2015年28期

【摘要】：目的:探讨模糊综合评价法在处方筛选中的应用。方法:以复方氨酚那敏颗粒为模型药物,在单因素试验基础上,以阿司帕坦、山楂粉末香精、鲜奶精粉末香精、蔗糖加入量为因素,咖啡因溶出度为指标,进行4因素3水平正交试验设计筛选处方;应用模糊综合评价法对正交试验9个处方所制颗粒从滋味、香气、色泽、溶化性方面进行感官评价。对优选处方进行验证试验并与原处方进行比较。结果:正交试验与模糊综合评价的最优处方均为处方5,结果一致;与原处方的感官综合得分和咖啡因溶出度(63.12分、91.3%)比较,优选处方3次验证试验中2个指标的平均值分别为84.00分、99.07%(RSD2.0%,n=3)。结论:模糊综合评价法可用于制剂中感官评价指标的处方筛选,其方法科学、结果准确。
[Abstract]:Objective: to explore the application of fuzzy comprehensive evaluation method in prescription screening.Methods: the compound aminophenamine granules were used as model drugs, and the dissolution of caffeine was determined by the factors of arsepartan, Hawthorn powder flavor, fresh milk essence powder flavor, sucrose content and caffeine dissolution rate on the basis of single factor test.Four factors and three levels of orthogonal design were carried out to screen the prescriptions, and the fuzzy comprehensive evaluation method was used to evaluate the taste, aroma, color and solubility of the granules produced by 9 prescriptions of the orthogonal test.The optimal prescription was tested and compared with the original prescription.Results: the optimal prescription of orthogonal test and fuzzy comprehensive evaluation were all prescription 5, the results were consistent with those of the original prescription, and were compared with the sensory synthesis score and caffeine dissolution rate (63.12 points, 91.3%) of the original prescription.The average values of the two indexes were 84.00 and 99.07respectively in the three tests of optimal selection of prescriptions, and the average values of the two indexes were 2.0% and 3.00%, respectively.Conclusion: the fuzzy comprehensive evaluation method can be used for the prescription screening of sensory evaluation index in the preparation. The method is scientific and the result is accurate.
【作者单位】：神威药业集团有限公司;中药注射剂新药开发技术国家地方联合工程实验室;
【基金】：国家科技重大专项石家庄高端医药产业园区创新药物孵化基地项目(No.2011ZX09401-306)
【分类号】：R943

【参考文献】