头孢维星在犬体内的药动学及生物利用度研究

发布时间：2018-04-14 18:09

本文选题：头孢维星 + 药动学　；参考：《中国兽药杂志》2015年06期

【摘要】：建立了一种头孢维星在犬血浆中的高效液相色谱检测法,并研究了头孢维星在犬体内的药动学特征及生物利用度。选用健康家犬12只,按单剂量(8 mg/kg b.w.)分别静脉注射或皮下注射头孢维星,利用建立的方法对头孢维星在犬血浆中的浓度进行测定,采用Win Nonlin5.2.1程序的非房室模型处理药时数据。结果显示,静脉注射组的主要药动学参数为t1/2β=129.15±35.79 h;MRT=152.56±44.95 h;λz=0.0059±0.0023 h-1;Cl=1.24±0.56 m L/(h·kg);AUC=6942.88±2462.48μgsIh/m L;V=170.20±28.09 m L/kg。皮下注射组的主要药动学参数为t1/2β=136.94±20.96 h;MRT=167.77±28.15 h;Tmax=0.83±0.26 h;Cmax=59.51±7.99μg/m L;λz=0.0052±0.0009 h-1;Cl=1.05±0.21 m L/(h·kg);AUC=7332.58±1118.30μg·h/m L;V=203.81±30.09 m L/kg;F=105.61%。结果表明,头孢维星在家犬体内表现出吸收迅速、消除缓慢、表观分布容积大、生物利用度高等药动学特点。
[Abstract]:A high performance liquid chromatography (HPLC) method for the detection of cefvericin in dog plasma was established. The pharmacokinetic characteristics and bioavailability of cefvericin in dogs were studied.Twelve healthy domestic dogs were selected, with a single dose of 8 mg/kg b.w.)Cefvericin was injected intravenously or subcutaneously. The concentration of cefovericin in dog plasma was determined by the established method. The data were processed by the non-atrioventricular model of Win Nonlin5.2.1 program.The results showed that the main pharmacokinetic parameters of the intravenous injection group were as follows: t 1 / 2 尾 n 129.15 卤35.79 h MRT = 152.56 卤44.95 h, 位 zN 0.0059 卤0.0023 h ~ (-1) Cln 1.24 卤0.56 mL / L 路h ~ (-1) 路kg ~ (-1) C ~ (1) C ~ (1) C _ (62.88) 卤2462.48 渭 gsIh/m / L V170.20 卤28.09 mL / kg 路h ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1) 路L ~ (-1).The results showed that cefvericin had the characteristics of rapid absorption, slow elimination, large apparent distribution volume and high bioavailability in domestic dogs.
【作者单位】：华南农业大学兽医学院;广东大华农动物保健品股份有限公司;
【基金】：广东省科技计划项目(2011B020306006)
【分类号】：R96

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