右兰索拉唑缓释胶囊在比格犬体内的药动学

发布时间：2018-04-14 23:03

  本文选题：右兰索拉唑 + 药动学　； 参考：《中国医院药学杂志》2017年14期

【摘要】：目的:研究右兰索拉唑缓释胶囊在比格犬体内的药动学特征。方法:将6只比格犬随机分为2组,采用双周期双交叉给药方法,单次灌胃60 mg右兰索拉唑缓释胶囊受试制剂或参比制剂,LC-MS/MS法测定比格犬体内右兰索拉唑血药浓度,计算药动学参数并进行生物等效性评价。结果:单次灌胃受试制剂和参比制剂后,比格犬血浆中右兰索拉唑的t1/2分别为(1.34±0.73)和(1.42±0.63)h,Tmax分别为(5.7±0.52)和(5.8±1.17)h,Cmax分别为(385.5±37.14)和(380.5±53.3)ng·mL~(-1),AUC0-t分别为(1 463.9±213.2)和(1 502.3±147.8)ng·h·mL~(-1),AUC0-∞分别为(1 476.4±215.7)和(1 514.3±149.5)ng·h·mL~(-1)。结论:右兰索拉唑缓释胶囊受试制剂与参比制剂在比格犬体内生物等效。
[Abstract]:Objective: to study the pharmacokinetics of desoprazole sustained-release capsules in Beagle dogs.Methods: six Beagle dogs were randomly divided into two groups. The blood concentration of dexlansoprazole was determined by single oral administration of 60 mg dexlansoprazole sustained release capsule or reference preparation (LC-MS / MS).Pharmacokinetic parameters were calculated and bioequivalence was evaluated.缁撴灉:鍗曟�＄亴鑳冨彈璇曞埗鍓傚拰鍙傛瘮鍒跺墏鍚�,姣旀牸鐘�琛�娴嗕腑鍙冲叞绱㈡媺鍞戠殑t1/2鍒嗗埆涓，

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