阿托伐他汀致肝功能异常的危险因素分析

发布时间：2018-04-17 08:06

  本文选题：他汀类药物 + 阿托伐他汀　； 参考：《中国新药与临床杂志》2015年10期

【摘要】：目的探讨阿托伐他汀致肝功能异常的危险因素,指导临床为患者提供药学监护,保证临床安全合理用药。方法选取2013年1月至12月在本院使用阿托伐他汀且资料完整的500例患者作为研究对象,对可能影响肝功能的诸多因素进行χ2检验、单因素分析和Cox多因素分析。结果肝功能异常的发生率为5.4%(27/500)。经单因素和多因素分析后显示,年龄≥60岁、饮酒≥500 g·周-1、合并用药(胺碘酮)与肝功能异常有关,是阿托伐他汀致肝功能异常的独立危险因素。结论老年人、饮酒和合并用药(胺碘酮)是阿托伐他汀致肝功能异常的危险因素,选用他汀类药物时应结合患者的个体情况,保证用药安全。
[Abstract]:Objective to explore the risk factors of abnormal liver function induced by Atto vastatin, to provide pharmacological monitoring for patients and to ensure safe and rational use of drugs in clinic.Methods from January to December, 2013, 500 patients with complete data who were treated with Atto vastatin in our hospital were selected as study subjects. 蠂 2 test, univariate analysis and Cox multivariate analysis were performed on many possible factors affecting liver function.Results the incidence of abnormal liver function was 5.4%.Univariate and multivariate analysis showed that age 鈮，

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