不同辅料对压敏胶黏附性能与流变性能的影响

发布时间：2018-04-17 10:49

本文选题：压敏胶 + 流变学　；参考：《中国医药工业杂志》2017年08期

【摘要】：基于不同压敏胶及含不同辅料压敏胶的黏附性能差异,运用流变学测试中的动态频率扫描模式,在频率0.01~100 Hz范围内对不同压敏胶及含促渗剂、共聚维酮S-630压敏胶的流变学行为进行对比研究,将压敏胶的宏观力学性能和聚合物流变学性质联系起来。结果表明,不同压敏胶表现出不同的黏附性能,且在流变学性质中呈现出不同的变化规律。压敏胶在低频率的储能模量(G')较小,初黏性较好;而低频率下的G'和复合黏度(η~*)较高,持黏性较好。当压敏胶中加入促渗剂时,可降低压敏胶在低频下的G'和η~*值,使初黏性升高、持黏性降低。而加入共聚维酮S-630则表现出与加入促渗剂相反的作用,这提示促渗剂和共聚维酮S-630在贴剂中发挥其促进药物透皮吸收、抑制药物析晶作用的同时,还对调节贴剂黏附性能起互补作用。
[Abstract]:Based on the different adhesion properties of different pressure-sensitive adhesives and pressure-sensitive adhesives containing different excipients, using the dynamic frequency scanning mode in rheological testing, different pressure-sensitive adhesives and percolating agents were used in the frequency range of 0.01 ~ 100 Hz.The rheological behavior of the pressure sensitive adhesive S-630 was compared and the macroscopic mechanical properties of the pressure sensitive adhesive were correlated with the rheological properties of the polymer.The results show that different pressure sensitive adhesives exhibit different adhesion properties and have different rheological properties.The low frequency storage modulus of pressure sensitive adhesive is smaller and the initial viscosity is better, while the G 'and complex viscosity (畏 _ (n)) are higher and the viscosity is better at low frequency.When the pressure-sensitive adhesive was added with a permeating agent, the G 'and 畏 ~ * values of the pressure-sensitive adhesive at low frequency were decreased, the initial viscosity increased and the viscosity decreased.However, the addition of copolymer Vitamin S-630 had the opposite effect as that of adding the permeating agent, which suggested that the osmotic enhancer and the copolymer Vitamin S-630 could promote the drug's transdermal absorption and inhibit the crystallization of the drug at the same time.It also plays a complementary role in adjusting the adhesive properties of the patch.
【作者单位】：中国医药工业研究总院药物制剂国家工程研究中心;
【基金】：国家“重大新药创制”科技重大专项(2014ZX09507006-002)
【分类号】：R943

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