左金胃黏附片的制备与体外释放度研究

发布时间：2018-04-17 17:08

本文选题：左金胃黏附片 + 体外释放　；参考：《中国药房》2015年25期

【摘要】：目的:制备左金胃黏附片并评价其体外释药性能。方法:以羟丙基甲基纤维素K15M(HPMC-K15M)、卡波姆934P、HPMC-E50为生物黏附剂和骨架材料,以碱式碳酸镁(发泡材料)、95%乙醇溶液(黏合剂)、微粉硅胶(助流剂、润滑剂)为辅料制备左金胃黏附片。以2、6、10 h黄连总生物碱累积释放度(Q2 h、Q6 h、Q10 h)为指标,采用正交设计试验对HPMC-K15M、卡波姆934P、HPMC-E50、碱式碳酸镁的用量进行优化,并进行验证。考察所制制剂与左金普通片的体外释药特性,并测定其体外黏附力。结果:最优处方为50片用量中含HPMC-K15M 0.7 g、卡波姆934P 0.2 g、HPMC-E50 3.5 g、碱式碳酸镁0.4 g;所制3批样品的Q2 h、Q6 h、Q10 h分别为24.32%、56.10%、77.04%;所制样品1~12 h的体外释药符合Ritger-Peppas方程。左金普通片和左金胃黏附片的Q2 h分别为80.46%、24.04%,Q12 h分别为92.15%、95.83%,胃黏附力分别为24.2、74.0 g/cm2。结论:成功制得具有缓释作用和黏附性能的左金胃黏附片。
[Abstract]:Objective: to prepare Zaojingwei adhesive tablet and evaluate its drug release in vitro.Methods: hydroxy propyl methyl cellulose (K15MN) HPMC-K15MN, Carbomer 934PNHPMC-E50 were used as biological adhesives and skeleton materials, and basic magnesium carbonate (foam material) 95% ethanol solution (adhesives, silica gel, lubricant) were used as auxiliary materials to prepare Zaojin gastric adhesive tablets.Taking the cumulative release of total alkaloids of Coptis chinensis for 10 h as an index, the dosage of HPMC-K15M, Carbomer 934P HPMC-E50 and basic magnesium carbonate were optimized and verified by orthogonal design.The in vitro release characteristics of the preparation and Zuo Jin tablets were investigated, and the adhesion in vitro was determined.Results: the optimum prescription was HPMC-K15M 0.7 g, carbomer 934P 0.2 g, HPMC-E 50 3.5 g, basic magnesium carbonate 0.4 g, Q2hm6hmOQ10 h of the three batches of samples were 24.32ian56.10 h and 77.04h, respectively, and the in vitro release of the samples for 112h was in accordance with the Ritger-Peppas equation.The Q2 h of Zuo Jin ordinary tablet and left Jin stomach adhesive tablet were 80.46% and 24.04 h, respectively, and Q12 h were 92.15% and 95.83%, respectively, and the gastric adhesion force was 24.2N 74.0 g / cm ~ 2 路cm ~ (2), respectively.Conclusion: the left gold stomach adhesive tablets with slow-release and adhesive properties were successfully prepared.
【作者单位】：第三军医大学第一附属医院药学部;
【分类号】：R944.4

【参考文献】