溶致液晶的制备、表征以及作为药物载体的应用

发布时间：2018-04-17 22:07

本文选题：溶致液晶 + 药物传递系统　；参考：《中国医院药学杂志》2017年18期

【摘要】：脂质已经被广泛地用作多种药物传递系统中的主要组分,例如脂质体、固体脂质纳米粒、纳米结构脂质载体和溶致液晶。其中,溶致液晶具有高度的有序性和热力学稳定的内部纳米结构,从而具有作为持续释放药物模型的潜力。立方相和六角相的复杂结构已经被证实能够为活性药物原料(不同的相对分子质量和极性)提供由扩散控制的释放。此外,脂质的生物可降解性和生物相容性证明了其具有最小的毒性并且可应用于多种给药途径。因此,近几年对溶致液晶的研究已经吸引了很多研究者的关注。本文将对溶致液晶的结构特点、制备方法、表征进行综述。此外,溶致液晶作为药物传递系统的最新研究进展将被进一步讨论。
[Abstract]:Lipids have been widely used as major components in many drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers and lyotropic liquid crystals.Among them, lyotropic liquid crystals have a high degree of order and thermodynamically stable internal nanostructures, which has the potential as a drug release model.The complex structures of cubic and hexagonal phases have been demonstrated to provide diffusion-controlled releases for active drug feedstocks (different relative molecular weights and polarities).In addition, the biodegradability and biocompatibility of lipids have proved that lipids have minimal toxicity and can be used in many drug delivery pathways.Therefore, the study of lyotropic liquid crystals has attracted many researchers' attention in recent years.In this paper, the structure, preparation and characterization of lyotropic liquid crystals are reviewed.In addition, the latest advances in lyotropic liquid crystals as drug delivery systems will be further discussed.
【作者单位】：南京军区福州总医院药学科;福建医科大学药学院;厦门大学医学院;福建中医药大学药学院;沈阳药科大学生命科学与生物制药学院;
【基金】：军队医疗机构制剂标准提高科研专项课题(编号:14ZJZ17)
【分类号】：R943

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