近十年上海医药工业研究院抗生素研发进展

发布时间：2018-04-19 14:03

本文选题：上海医药工业研究院 + 抗生素仿制药　；参考：《中国医药工业杂志》2017年03期

【摘要】：本文介绍了上海医药工业研究院近10年来通过抗生素产生菌的菌种选育、发酵和分离纯化工艺以及生物转化等技术,在抗生素仿制药开发和已有产品的新工艺开发,以及抗生素创新药物研究方面取得的一些进展。在抗生素仿制药开发方面,成功开发了多黏菌素E甲磺酸钠、达托霉素、奥利万星和达巴万星等品种;以及抗真菌抗生素米卡芬净、卡帕芬净和阿尼芬净等品种。在抗生素新工艺开发方面,成功开发了林可霉素、纳他霉素、依替米星、去甲金霉素、他克莫司、雷帕霉素、依维莫司、埃博霉素、喷司他丁、腺苷甲硫氨酸和谷胱甘肽等发酵工艺,以及利用生物转化,成功开发了7,15-二羟基去氢表雄酮、阿扎那维、克唑替尼、左乙拉西坦手性前体制备等工艺。在抗生素创新药物方面,取得了一些具有很好开发前景的临床前候选化合物。在过去10年里,我们的30余个项目在国内20多家企业进行了开发并实现了产业化,其中获国家科技进步奖二等奖2项、上海市科技进步奖一等奖2项、浙江省科技进步二等奖1项,以及中国优秀专利奖2项。
[Abstract]:In the past 10 years, Shanghai Institute of Pharmaceutical Industry has introduced the development of antibiotic generic drugs and the new technology of existing products through the breeding of antibiotic producing bacteria, fermentation, separation and purification technology and biotransformation technology.And some advances in the research of antibiotics and innovative drugs.In the field of antibiotic generic drug development, the varieties of sodium polymyxin E methanesulfonate, daptomycin, olipamicin and dabavanxin were successfully developed, as well as the antifungal antibiotics mikafenjing, carbafenem and Aniphen.In the development of new antibiotic technology, lincomycin, natamycin, etemicin, nortetracycline, tacrolimus, rapamycin, Ivimus, epomycin, pencastatin,The fermentation process of adenosine methionine and glutathione and the preparation of chiral precursors of 7F15 dihydroxydehydroepiandrosterone, Azanavir, kazolinib and levoethylacetam were successfully developed by biotransformation.In the field of antibiotic innovation, some pre-clinical candidate compounds have been obtained.In the past 10 years, our more than 30 projects have been developed and industrialized in more than 20 enterprises in China. Among them, we have won two second prize of the National Science and Technology Progress Award and two first prize of Shanghai Science and Technology Progress Award.Zhejiang province science and technology progress second prize, and China outstanding patent award 2.
【作者单位】：中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室;
【分类号】：R978.1

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