铁代谢体系影响抗生素杀菌作用的研究进展

发布时间：2018-04-20 07:08

本文选题：铁代谢 + 抗生素　；参考：《中国抗生素杂志》2016年08期

【摘要】：传统研究认为不同种类的抗生素有其各自不同的杀菌途径,然而近年人们发现了一条抗生素杀菌的共用通路,那就是当细菌细胞受到抗生素致死性刺激时,呼吸链代谢异常产生大量活性氧簇(ROS),而铁离子对ROS介导的杀菌至关重要。本文参阅近年来国内外研究结果,介绍了铁吸收、储存和利用有关的细菌铁代谢系统及其调控机制,重点讨论铁离子的调控及其与抗生素介导的ROS形成的相互作用关系。对于细菌耐药机制的研究与寻找新型药物作用靶点,探索有效控制手段和开发新药有重要意义。
[Abstract]:Traditional research suggests that different kinds of antibiotics have their own different ways of killing bacteria. However, in recent years, a common pathway of antibiotic sterilization has been discovered, that is, when bacterial cells are stimulated by antibiotics, Abnormal respiratory chain metabolism produces a large number of reactive oxygen species (Ros), and iron ions are essential for ROS mediated sterilization. In this paper, referring to the domestic and foreign research results in recent years, this paper introduces the iron metabolism system and its regulatory mechanism related to the absorption, storage and utilization of iron, with emphasis on the regulation of iron ions and their interaction with the formation of ROS mediated by antibiotics. It is of great significance to study the mechanism of bacterial drug resistance, to find new drug targets, to explore effective control methods and to develop new drugs.
【作者单位】：分子疫苗学和分子诊断学国家重点实验室厦门大学;
【基金】：国家自然基金(No.81473251/81301474/31370166) 福建省自然科学基金(No.2014J01139/2015J01345) 国家重点基础研究发展计划(973计划)前期研究专项(No.2014CB560710)
【分类号】：R96

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