罗布麻双层漂浮型脉冲释药片的制备

发布时间：2018-04-22 14:48

本文选题：罗布麻 + 漂浮型脉冲释药系统　；参考：《中成药》2015年04期

【摘要】：目的制备用于节律性高血压治疗的罗布麻提取物漂浮型脉冲释药片。方法以崩解时间和溶出度为指标,筛选罗布麻提取物速释片芯的崩解剂,用混料设计优选最佳漂浮层处方,体外释药试验考察对时滞的影响。结果优选的处方和工艺条件为:交联聚维酮(PVPP)作为片芯崩解剂;包衣处方中羟丙甲基纤维素(HPMC K4M)作为凝胶材料,乳糖用量为20%;漂浮层以30%卡波姆(carbopol)、36.3%羟丙甲基纤维素、33.7%碳酸氢钠组合最优。体外释放试验表明,罗布麻双层漂浮型脉冲片在经6 h滞期后药物脉冲释放。结论罗布麻双层漂浮型脉冲片达到瞬间起漂并持续到预定的时滞期脉冲释药,满足节律性疾病的治疗要求。
[Abstract]:Objective to prepare floating pulsed release tablets of Apocynum Apocynum extract for the treatment of rhythmic hypertension. Methods based on the disintegration time and dissolution rate, the disintegrating agent of the quick release tablets of Apocynum acutum extract was selected, and the best prescription of floating layer was selected by the mixture design. The effect of drug release test in vitro on the time delay was investigated. Results the optimized prescription and technological conditions were as follows: crosslinked PVPP1 as core disintegrating agent, HPMC K4M as gel material, HPMC K4M as gel material, HPMC K4M as gel material, HPMC K4M as gel material, and HPMC K4M as gel material. The dosage of lactose was 20. The optimum combination of the floating layer was 36.3% hydroxypropyl methyl cellulose and 33.7% sodium bicarbonate in the floating layer. The in vitro release test showed that the drug pulse release of Apocynum bilayer floating pulsatile was delayed for 6 hours. Conclusion the floatation pulse tablets of Apocynum bilayer can bleach instantly and continue to the scheduled time-lag pulse release, which can meet the treatment requirements of rhythmic diseases.
【作者单位】：成都中医药大学中药标准化教育部重点实验室中医药资源及开发利用国家重点实验室培育基地;
【基金】：四川省教育厅项目(12ZA042)
【分类号】：R943

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