透明质酸修饰的氧化石墨烯负载米托蒽醌载药体系在乳腺癌模型裸鼠体内的药动学特征和组织分布

发布时间：2018-04-23 01:29

  本文选题：米托蒽醌 + 透明质酸　； 参考：《郑州大学学报(医学版)》2017年05期

【摘要】：目的:考察透明质酸(HA)修饰的氧化石墨烯(GO)负载米托蒽醌(MIT)载药体系(MIT/HA-GO)在乳腺癌模型裸鼠体内的药动学特征和组织分布。方法:建立MIT测定的高效液相色谱法。荷瘤小鼠由尾静脉分别注射MIT、MIT/GO以及MIT/HA-GO,用上述方法检测MIT浓度,分析其在小鼠体内的药动学特征及在心、肝、肺、肾、瘤等部位的分布情况。结果:与MIT组相比,MIT/GO组及MIT/HA-GO组MIT的血循环时间均延长,且在心、肺、肾的AUC降低;MIT/GO及MIT/HA-GO在肿瘤组织的靶向效率分别为MIT的1.55和2.61倍。结论:MIT/HA-GO载药体系降低了MIT的全身毒副作用并提高了对肿瘤部位的靶向性。
[Abstract]:Aim: to investigate the pharmacokinetic characteristics and tissue distribution of mitoxantrone (mitoxantrone) -loaded mitoxantrone (mitoxantrone) loaded with hyaluronic acid (HA) in nude mice with breast cancer. Methods: high performance liquid chromatography (HPLC) was established for the determination of MIT. Mice bearing tumor were injected into tail vein with Mitt / MIT / go and MIT / HA-GO.The concentration of MIT was detected by the above method, and the pharmacokinetic characteristics and distribution of heart, liver, lung, kidney and tumor in mice were analyzed. Results: compared with the MIT group, the blood circulation time of MIT in both the mitr / go group and the MIT/HA-GO group was prolonged, and the AUC in heart, lung and kidney decreased the targeting efficiency of MIT/HA-GO and MIT/HA-GO in tumor tissue by 1.55 and 2.61 times of MIT, respectively. Conclusion the MIT system can reduce the systemic toxicity of MIT and improve the targeting of tumor site.
【作者单位】： 郑州大学药学院;
【基金】：国家自然科学基金资助项目81202485,81273451
【分类号】：R-332;R965
，

本文编号：1789857