61例伏立康唑血药浓度结果分析

发布时间：2018-04-24 07:16

本文选题：伏立康唑 + 血药浓度　；参考：《中国医院药学杂志》2016年09期

【摘要】：目的:对伏立康唑开展血药浓度监测(TDM)的结果进行分析,阐明TDM对伏立康唑合理用药的必要性。方法:本研究通过回顾性分析伏立康唑TDM的结果,从性别、年龄、剂量与浓度相关性,浓度分布情况以及质子泵抑制剂(PPIs)对伏立康唑血药浓度的影响等多方面进行分析探讨。结果:伏立康唑血药浓度个体差异较大,其中1.0μg·mL-1有12例,1.0~2.0μg·mL-1有15例,2.0~5.5μg·mL-1有25例,5.5μg·mL-1有9例;剂量与浓度无明显相关性(R2=0.172);老年组(60岁)vs非老年组(60岁)(P=0.19)、男性组vs.女性组(P=0.27)。当联用PPIs时,随着PPIs对CYP2C19抑制程度的增加,伏立康唑血药浓度呈上升趋势,但组间无统计学意义。结论:伏立康唑血药浓度个体差异大,大部分患者使用后浓度不在治疗窗范围内。开展伏立康唑TDM有利于提高临床效应和提高安全性。
[Abstract]:Objective: to analyze the results of plasma drug concentration monitoring (TDM) with voliconazole, and to clarify the necessity of rational use of TDM for Volconazole. Methods: the results of Volconazole TDM were retrospectively analyzed, and the effects of sex, age, dose and concentration, concentration distribution and proton pump inhibitor (PPP) on the plasma concentration of Volconazole were analyzed. Results: there were significant individual differences in the plasma drug concentration of vericonazole, including 1.0 渭 g mL-1 in 12 patients with 1.0 渭 g mL-1, 15 patients with 2.0 渭 g mL-1, 15 patients with 2.0 渭 g mL-1 and 25 patients with 5.5 渭 g mL-1. There was no significant correlation between the dose and the concentration of the drug, and there was no significant correlation between the dosage and the concentration of the drug, and there was no significant correlation between the dosage and the concentration of the drug, and the aged group was 60 years old vs the non-elderly group (60 years old), and the male group was Vs0.190.There was no significant correlation between the dose and the concentration. The female group was 0.27. When combined with PPIs, with the increase of inhibition of CYP2C19 by PPIs, the plasma concentration of voriconazole showed an increasing trend, but there was no statistical significance between groups. Conclusion: there is a large individual difference in the plasma concentration of Volconazole, and the concentration is not within the scope of the treatment window after the use of most patients. Volconazole TDM is helpful to improve clinical efficacy and safety.
【作者单位】：昆明医科大学第一附属医院临床药学科;云南省第三人民医院信息中心;
【基金】：云南省医疗卫生单位内设研究机构科研项目(编号:2016NS069)
【分类号】：R969

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