我院静脉用药调配中心净化空调系统的管理与维护

发布时间：2018-04-28 10:03

本文选题：静脉用药调配中心 + 净化空调系统　；参考：《中国药房》2015年34期

【摘要】：目的:完善静脉用药调配中心(PIVAS)净化空调系统的维护管理体系,进一步加强洁净环境的管理。方法:从温湿度及压差值记录、空气悬浮粒子检测、沉降菌检测3个方面介绍我院PIVAS净化空调系统开展的洁净度监测项目,并对监测结果进行分析。结果:我院PIVAS洁净区的温湿度及压差值基本符合2010年版《静脉用药集中调配质量管理规范》的规定,即温度在18~26℃、相对湿度在40%~65%;抗生素类、危害药品调配区和二次更衣室之间应当呈5~10 Pa负压差。洁净区各洁净度级别的空气悬浮粒子数(静态平均数/m3)均达到了2010年版《药品生产质量管理规范》的规定,即洁净区空气悬浮粒子(≥0.5μm)最大允许数为3 520个/m3(100级)、352 000个/m3(10 000级)、3 520 000个/m3(100 000级)。洁净区静态沉降菌检测合格率达到100%,符合《医药工业洁净室(区)沉降菌的测试方法》的规定,即沉降菌(90 mm)CFU/0.5 h≤1(100级)、≤3(10 000级)、≤10(100 000级);但动态条件下的沉降菌检测合格率不高,尤其是配置间和二次更衣间检查合格率仅为80%。结论:应进一步完善净化空调系统管理和维护的标准操作规程,科学、全面地管理和维护净化系统,对有效控制PIVAS所配制输液造成的医院感染率、提高静脉输液的质量、保障患者用药安全至关重要。
[Abstract]:Objective: to improve the maintenance and management system of the PIVAS purifying air conditioning system, and to further strengthen the management of the clean environment. Methods: from 3 aspects of the temperature and humidity and pressure difference record, the air suspension particle detection and the sedimentation bacteria detection, the cleanliness monitoring project of the PIVAS cleaning air conditioning system in our hospital is introduced, and the monitoring results are carried out. Results: the temperature, humidity and pressure difference in the PIVAS clean area of our hospital basically conform to the regulation of the standard of quality management in the 2010 edition of the centralized allocation of intravenous medication, that is, the temperature is at 18~26 C, relative humidity is in 40%~65%, the antibiotic type, the negative pressure difference between the drug dispensing area and the two dressing room should be 5~10 Pa negative pressure. The air cleanliness grade of the clean area The number of suspended particles (static average /m3) reached the provisions of the 2010 edition of the standard for quality management of drug production, that is, the maximum allowable number of air suspended particles in the clean area (> 0.5 mu m) is 3520 /m3 (100), 352000 /m3 (10000) and 3520000 /m3 (100000). The qualification rate of the static settling bacteria in the clean area is 100%, in accordance with the medical workers. The test method of the sedimentation bacteria in the clean room (area) was defined as the sedimentation bacteria (90 mm) CFU/0.5 h < 1 (Grade 100), less than 3 (10000 grade) and less than 10 (100000 grade), but the detection rate of the sedimentation bacteria under dynamic conditions was not high, especially the coincidence rate between the configuration and two dressing rooms was only the conclusion that the management and maintenance of the purification air conditioning system should be further perfected. The standard operating procedures, scientific and comprehensive management and maintenance of the purification system are essential for the effective control of the hospital infection rate caused by the infusion of PIVAS, the improvement of the quality of intravenous infusion and the safety of the patient's drug use.

【作者单位】：安徽医科大学第一附属医院药剂科/国家中医药管理局中药化学三级实验室;
【分类号】：R95

【参考文献】