新型干粉吸入剂载体:含纳米孔结构的药用花形载体乳糖微粒

发布时间：2018-04-29 05:14

本文选题：干粉吸入剂 + 载体　；参考：《药学学报》2017年09期

【摘要】：本研究制备了一种新型的干粉吸入剂载体,并用于噻托溴铵的吸附和脱附应用。合成的药用花形载体乳糖微粒呈结晶态,含微-介-大孔均匀分布的孔结构,且具有高孔隙率、高载药量和高药物释放效率的优点。在噻托溴铵吸附研究中,采用溶液吸附法结合的噻托溴铵分子集中分布在花形微粒的内部,载体形貌变化小,测得的药物吸附量为5%(w/w,固体质量比),而采用结晶吸附法结合的噻托溴铵分子集中分布在花形微粒的外部,载体形貌变化大,测得的药物吸附量为49%(w/w)。此外,在载体的几何形貌影响下,采用溶液吸附法制备的制剂,其药物释放速率先快后慢;而采用结晶吸附法制备的制剂,其药物释放速率先慢后快。因此,该乳糖微粒可作为一种新型的药用载体,用于干粉吸入剂。
[Abstract]:In this study, a new dry powder absorbent carrier was prepared and used for the adsorption and desorption of thiotropium bromide. The synthesized drug flower carrier lactose particles are crystalline, with micromeso-macroporous pore structure, and have the advantages of high porosity, high drug loading and high drug release efficiency. In the study of thiotropium bromide adsorption, the tiotropium bromide molecules combined with the solution adsorption method were concentrated inside the floral particles, and the morphology of the carrier changed little. The drug adsorption capacity was measured to be 5w / w, and the solid mass ratio was obtained. However, the tiotropium bromide molecules combined with crystal adsorption method were concentrated on the outside of the flower-shaped particles, and the morphology of the carrier changed greatly. The drug adsorption capacity measured was 49w / w / w ~ (-1). In addition, under the influence of the geometric morphology of the carrier, the drug release rate of the preparation prepared by solution adsorption method was first fast and then slow, while the drug release rate of the preparation prepared by crystal adsorption method was first slow and then fast. Therefore, the lactose particles can be used as a new drug carrier for dry powder inhalation.
【作者单位】：澳高科公司;长沙方圆咨询有限公司;韩国高丽大学生物医药工程系;澳大利亚悉尼科技大学工程学院;
【基金】：澳高科公司企业资助项目(Auhightech 2017001)
【分类号】：R943

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