临床科室华法林用药特点分析

发布时间：2018-04-30 05:33

本文选题：华法林 + 临床应用　；参考：《中国临床药理学杂志》2015年24期

【摘要】：目的分析临床各科室针对不同适应证使用华法林的用药特点。方法回顾性分析2013年6月至2014年7月北京大学第一医院各临床科室华法林的用药特点,包括华法林起始剂量及出院维持剂量、与低分子肝素/普通肝素重叠治疗时间、国际标准化比值(INR)初次监测的时间与频率、出院INR值、非治疗范围INR或出血的处理方式。结果共调查应用华法林的11个临床科室,12项适应证的219例病例,其中男115例,女104例,年龄16~88岁。各临床科室华法林用药特点在持续应用组比较差异无统计学意义(P0.05),在首次应用组中差异表现突出。结论临床药师在指导华法林用药时,应针对各临床科室患者基本特征、各适应证选择合适的初始剂量,进行规律监测INR,适宜的抗凝强度,同时注意加强患者用药教育,才能在预防血栓栓塞事件发生的同时减少出血事件发生。
[Abstract]:Objective to analyze the characteristics of warfarin for different indications in clinical departments. Methods from June 2013 to July 2014, the characteristics of warfarin used in clinical departments of the first Hospital of Peking University were analyzed retrospectively, including the initial dose of warfarin and the dose of discharge maintenance, and overlapped with low molecular weight heparin (LMWH) / ordinary heparin (LMWH). The time and frequency of the first monitoring, the INR value of discharge, the treatment of non-therapeutic range INR or bleeding. Results A total of 219 cases (115 males and 104 females, aged 1688 years) with 12 indications of warfarin in 11 clinical departments were investigated. There was no significant difference in the characteristics of warfarin used in each clinical department in the continuous application group, but the difference was significant in the first application group. Conclusion in directing warfarin administration, clinical pharmacists should select appropriate initial dosage according to the basic characteristics of patients in each clinical department, carry out regular monitoring of INR, appropriate anticoagulant intensity, and pay attention to strengthening the education of drug use in patients. In order to prevent the occurrence of thromboembolic events while reducing the incidence of bleeding.
【作者单位】：北京大学第一医院药剂科;安徽医科大学第一附属医院药剂科;
【基金】：国家自然科学基金资助项目(81273592,81202592)
【分类号】：R969.3

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