果胶-壳聚糖-卵磷脂复合凝胶球结肠给药的性能考察

发布时间：2018-05-01 00:05

  本文选题：果胶 + 结肠给药系统　； 参考：《中国医药工业杂志》2017年09期

【摘要】：探讨壳聚糖和卵磷脂对果胶凝胶球的改性作用,以酮洛芬(KTP)为药物模型,对比不同交联剂(Ca~(2+)和Zn~(2+))形成的果胶-壳聚糖-卵磷脂复合凝胶球的性能。通过改变处方的壳聚糖浓度、卵磷脂浓度、交联剂p H值等进行单因素试验,考察各因素对凝胶球粒径、粒重、载药量、包封率和体外释药的影响。结果表明,壳聚糖的加入对钙体系和锌体系的凝胶球载药量影响不大;随着卵磷脂的加入,2种凝胶球的载药量都呈现降低趋势;2种凝胶球的包封率都在一定范围内随着壳聚糖和卵磷脂浓度的增加而升高。载KTP的钙体系果胶-壳聚糖-卵磷脂复合凝胶球在模拟小肠(SIF)阶段释药90%以上,达不到结肠给药的目的 ;锌体系果胶-壳聚糖-卵磷脂复合凝胶球在SIF阶段释药10%,在模拟结肠液(SCF)阶段释药83.21%,提示壳聚糖、卵磷脂共同改性的果胶锌凝胶球有一定的结肠给药效果。
[Abstract]:The effects of chitosan and lecithin on the modification of pectin gel spheres were studied. Using ketoprofen KTPas as drug model, the properties of pectin chitosan lecithin composite gel spheres formed by different crosslinking agents (Zn~(2) and different crosslinkers were compared. By changing the concentration of chitosan, the concentration of lecithin and the value of crosslinking agent pH, the effects of various factors on the particle size, particle weight, drug loading, encapsulation efficiency and drug release in vitro were investigated. The results showed that the addition of chitosan had little effect on the amount of gels loaded in calcium and zinc systems. With the addition of lecithin, the drug loading of the two kinds of gels showed a decreasing trend. The entrapment efficiency of the two kinds of gels increased with the increase of chitosan and lecithin concentration in a certain range. Pectin-chitosan-lecithin composite gel spheres loaded with KTP released more than 90% of the drugs in the simulated small intestinal sif stage, which could not achieve the purpose of colonic administration. In zinc system, Pectin / chitosan / lecithin composite gel spheres released 10 drugs at SIF stage and 83.21 at simulated colonic fluid stage, suggesting that chitosan and lecithin modified Pectin zinc gel spheres have a certain colonic drug delivery effect.
【作者单位】： 天津科技大学化工与材料学院;
【分类号】：R943
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本文编号：1826823