我院华法林与抗肿瘤药物及辅助用药相互作用的医嘱分析

发布时间：2018-05-03 00:07

本文选题：华法林 + 抗肿瘤药物　；参考：《中国药房》2017年12期

【摘要】：目的:分析和总结华法林与抗肿瘤药物和相关辅助药物的相互作用,为临床安全用药提供参考。方法:采用回顾性分析的方法,通过医院信息管理系统调取2006年1月-2015年12月我院住院患者使用华法林的医嘱,提取患者基本信息、适应证、华法林用法用量、国际标准化比值(INR)等,并依据MICROMEDEX 2.0数据库中的药物相互作用评价标准予以总结,并查阅相关文献予以确证。结果:共纳入72条医嘱,合计56例患者,其中14条医嘱在抗肿瘤治疗过程中华法林的用药剂量有调整,推断可能发生了相互作用。MICROMEDEX 2.0评价共有17种药物与华法林存在相互作用,等级为"严重"的有厄洛替尼、氟尿嘧啶、卡培他滨、依托泊苷、卡铂、长春新碱、布洛芬。结论:华法林与多种抗肿瘤药物和相关辅助药物存在相互作用。临床在华法林与肿瘤化疗药物和相关辅助药物联用时,应严密监测患者INR值,做好预防措施,保障患者的用药安全。
[Abstract]:Objective: to analyze and summarize the interaction of warfarin with antineoplastic drugs and related adjuvant drugs. Methods: the hospital information management system was used to collect the warfarin medical advice from January 2006 to December 2015. The basic information, indications and usage of warfarin were extracted. According to the evaluation criteria of drug interaction in MICROMEDEX 2.0 database, the international standardized ratio (INR) was summarized, and the relevant literature was consulted to confirm it. Results: a total of 72 medical orders were included in 56 patients, of which 14 were adjusted in the dosage of warfarin during antitumor therapy, and it was inferred that there might have been interaction between 17 drugs and warfarin in the evaluation of .MICROMEDEX 2.0. Grade "severe" include erlotinib, fluorouracil, capecitabine, etoposide, carboplatin, vincristine, ibuprofen. Conclusion: warfarin interacts with various anti-tumor drugs and related adjuvant drugs. In clinical use of warfarin combined with tumor chemotherapeutic drugs and related adjuvant drugs, the INR value of patients should be closely monitored, and preventive measures should be taken to ensure the safety of drug use.
【作者单位】：北京大学肿瘤医院暨北京市肿瘤防治研究所药剂科/恶性肿瘤发病机制及转化研究教育部重点实验室;北京大学医学部临床药学与药事管理系;
【分类号】：R969.2

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