基于关联规则的静脉注射药物相互作用分析及应用系统研究

发布时间：2018-05-04 09:02

本文选题：关联规则 + APRIORI算法　；参考：《昆明理工大学》2016年硕士论文

【摘要】：安全用药直接关系到医疗效果和患者的生命安全,保障患者用药安全一直是医院药学服务质量管理工作的重中之重。由于不懂药物“相克”原理导致全球众多病人死于不合理用药。仅老年人死亡人数中就有七分之一死于不合理用药,而不是自然衰老或疾病。因而,基于药学服务链全过程的安全用药监管关键技术研发成为当务之急。本文提出使用关联规则挖掘对药物相互作用数据进行挖掘,关联规则作为数据挖掘中的重要组成部分,可以挖掘出药物相互作用数据中潜在的、有价值的关联信息,有利于临床治疗和用药安全。最后设计并实现了静脉注射药物相互作用分析系统。目前大多数静配中心的系统中,药物数据只是简单地储存在数据库中,对药物数据的处理还处在简单的数据查询、修改和删除等状态,并没有真正释放出信息技术的潜能。针对这一难题,本课题运用对关联规则技术的研究,设计并实现了静脉注射药物相互作用分析系统。在论文中作者做了以下几方面的工作：(1)介绍了关联规则挖掘的概念和性质以及挖掘过程；然后对关联规则中的APRIORI算法的思想、算法挖掘过程和优缺点进行了介绍,并运用例子对算法挖掘过程进行了讲解；最后对APRIORI算法做出了改进,通过实验仿真,结果显示效果良好。(2)研究了药物相互作用的概念和定义、表型形式以及研究意义；然后对2009年版的《药物相互作用基础与临床》和2015年版的《静脉用药物调配技术》这两本书中的抗感染类药物数据进行了数据处理,将处理后的药物数据按避免合用、可以合用和谨慎合用三类,并分别对这三类药物数据进行了关联规则挖掘,挖掘药物之间的相互作用关系,得出关联规则,并对挖掘结果进行评价。(3)对静脉注射药物相互作用分析系统的设计与实现过程进行了详细分析,主要从三个部分对系统的设计实现过程进行说明。第一部分,系统的需求分析,这里主要是对系统的业务流程和系统的用例进行分析,其中业务流程包含业务流程分析和角色分析；第二部分,系统的数据分析,这里主要是对系统功能数据的分析、系统实体类关系分析以及系统的数据库表；第三部分,系统构架,这里主要讲解了系统使用了哪些技术,并对系统进行了功能展示。本文设计并实现了静脉注射药物相互作用分析系统,由于该系统设计的可行性和操作的实用性,目前该系统已在云南省某着名三甲医院静配中心实施应用。经过一段时间的实际使用,效果反应良好。最后,基于整体工作的总结,对该系统的后续设计工作,以及针对药物相互作用分析工作做出了展望。
[Abstract]:Safe use of drugs is directly related to the effect of medical treatment and the safety of patients' lives. It has always been the most important task in the quality management of hospital pharmaceutical care to ensure the safety of drug use of patients. Many patients worldwide died of irrational use of drugs because they did not understand the principle of drugs. 1/7 of the elderly die from irrational drugs, not natural aging or disease. Therefore, the research and development of the key technology of drug safety supervision based on the whole process of pharmaceutical service chain becomes an urgent matter. In this paper, association rule mining is proposed to mine drug interaction data. As an important part of data mining, association rules can mine potential and valuable association information from drug interaction data. It is beneficial to clinical treatment and safety of drug use. Finally, an intravenous drug interaction analysis system is designed and implemented. At present, in most systems of static distribution center, the drug data is simply stored in the database, and the processing of the drug data is still in the state of simple data query, modification and deletion, which does not really release the potential of information technology. In order to solve this problem, an intravenous drug interaction analysis system is designed and implemented by the research of association rules. In this paper, the author has done the following work: 1) introduced the concept and nature of association rule mining and the mining process, then introduced the idea, algorithm mining process, advantages and disadvantages of APRIORI algorithm in association rules. An example is used to explain the algorithm mining process. Finally, the APRIORI algorithm is improved. The experimental results show that the effect is good. (2) the concept and definition of drug interaction, phenotypic form and research significance are studied. Then the data of anti-infective drugs in the 2009 edition of the basic and Clinical aspects of Drug interaction and the 2015 edition of Drug blending techniques for intravenous use were processed to avoid sharing the processed drug data. Three kinds of drugs can be used together and carefully, and the association rules of these three kinds of drug data are mined, and the interaction relationship between drugs is mined, and the association rules are obtained. The design and implementation process of the intravenous drug interaction analysis system is analyzed in detail, and the design and implementation process of the system is explained from three parts. The first part, the requirement analysis of the system, mainly analyzes the business process of the system and the use case of the system, in which the business process includes the business process analysis and the role analysis; the second part, the data analysis of the system, Here is the analysis of the system function data, the system entity class relation analysis and the system database table; the third part, the system structure, here mainly explained which technology the system used, and has carried on the function display to the system. An intravenous drug interaction analysis system has been designed and implemented in this paper. Due to the feasibility of the system design and the practicability of operation, the system has been applied in the static distribution center of a famous third Class A Hospital in Yunnan Province. After a period of practical use, the effect is good. Finally, based on the summary of the whole work, the future design of the system and the analysis of drug interaction are prospected.
【学位授予单位】：昆明理工大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：TP311.13;R969.2

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