组蛋白去乙酰化酶抑制剂放射增敏作用与DNA损伤修复机制关系的研究进展

发布时间：2018-05-05 08:06

本文选题：组蛋白去乙酰化酶抑制剂 + 辐射耐受性　；参考：《中国药理学与毒理学杂志》2015年04期

【摘要】：组蛋白去乙酰化酶抑制剂(HDACIs)是抑制HDAC活性并造成组蛋白过度乙酰化作用的一类化合物,根据其化学结构的特点,HDACIs化合物被分成短链脂肪酸、异羟肟酸、环肽和苯甲酰胺四大类。研究表明,HDACIs能抑制多种肿瘤细胞的生长,某些具有抗肿瘤作用的HDACIs已经进入临床试验阶段。近年来还发现,HDACIs能增加肿瘤细胞对电离辐射的敏感性,具有较强的放射增敏作用,但该类化合物的放射增敏机制目前还不十分清楚,可能与其能增强肿瘤细胞的凋亡和自噬作用,以及DNA损伤修复机制破坏等有关,其中HDACIs通过导致DNA双链断裂修复机制障碍发挥放射增敏作用已越来越引起学者们的关注。为此,本文就HDACis的放射增敏作用与DNA损伤修复机制之间关系的研究进行综述。
[Abstract]:Histone deacetylase inhibitor (HDACIs) is a class of compounds which inhibit the activity of HDAC and cause histone hyperacetylation. According to its chemical structure, HDACIs are divided into four categories: short chain fatty acid, hydroxamic acid, cyclic peptide and benzoamide. Studies have shown that HDACIs can inhibit the growth of many kinds of tumor cells, and some antitumor HDACIs have entered the clinical trial stage. In recent years, it has been found that HDACIs can increase the sensitivity of tumor cells to ionizing radiation and have a strong radiosensitization effect, but the mechanism of radiosensitization of HDACIs is not very clear. It may be related to the enhancement of apoptosis and autophagy of tumor cells, and the destruction of DNA damage and repair mechanism. Among them, the radiosensitization of HDACIs through the mechanism of double-strand break repair of DNA has attracted more and more attention. In this paper, the relationship between the radiosensitization of HDACis and the repair mechanism of DNA damage was reviewed.
【作者单位】：山东大学齐鲁医院药学部;山东大学公共卫生学院职业卫生与职业医学系;
【基金】：国家自然科学基金(81172527);国家自然科学基金(81472800) 山东省科技发展计划(2013GGE27052)~~
【分类号】：R96

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