ABCB1 C3435T多态性与中国人群中他汀类药物疗效关系的系统评价

发布时间：2018-05-05 14:36

  本文选题：ABCB + 多态性　； 参考：《中国药学杂志》2017年12期

【摘要】：目的探讨ABCB1 C3435T基因多态性与中国人群中他汀类药物疗效的关系。方法计算机检索PubMed、Web of Science、Cochran Library、CNKI、Wan Fang Data、VIP。检索时间均从建库至2016年8月10日。采用非随机试验性研究的质量评价表进行质量评价。统计分析通过Rev Man 5.3软件实现。结果共纳入4个研究,630名研究对象。显性遗传模型TC+CC vs.TT、隐性遗传模型CC vs.TT+TC、加性遗传模型CC vs.TT中ABCB1 C3435T基因多态性与中国人群中他汀对HDL-C、LDL-C、TC、TG影响的相关性均无统计学意义。结论基于本研究结果,尚不能认为ABCB1 C3435T基因多态性与中国人群中他汀疗效有关联。期待今后针对中国人群开展更大样本、多中心、治疗随访时间较长、高质量的研究。
[Abstract]:Objective to investigate the relationship between the polymorphism of ABCB1 C 3435 T gene and the efficacy of statins in Chinese population. Methods A computer-based search was conducted for the Fang Fang of Fang in PubMedus. The retrieval time was from the construction of the database to August 10, 2016. The quality evaluation table of non-random experimental study was used to evaluate the quality. The statistical analysis is realized by Rev Man 5.3 software. Results A total of 630 subjects were included in 4 studies. There was no significant correlation between the polymorphism of ABCB1 C3435T gene in CC vs.TT and the effect of statins on the TG of HDL-Cn LDL-CfT in Chinese population, including the dominant genetic model TC CC vs.TTT, the recessive genetic model CC vs.TT TC, and the additive genetic model CC vs.TT. Conclusion based on the results of this study, we can not conclude that the polymorphism of ABCB1 C3435T gene is associated with the efficacy of statins in Chinese population. In the future, we hope to carry out a larger sample, multi-center, longer treatment follow-up and high quality research for Chinese population.
【作者单位】： 北京大学中日友好临床医学院药学部;北京大学药学院药事管理与临床药学系;
【基金】：国家自然科学基金资助项目(81302843)
【分类号】：R969
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本文编号：1848067