处方组成对槲皮素传递体透皮作用的影响

发布时间：2018-05-05 21:40

本文选题：槲皮素 + 处方　；参考：《中国医药工业杂志》2017年04期

【摘要】：采用注入法-高压均质法制备槲皮素(1)传递体。采用改良Franz扩散池法,考察不同表面活性剂(Tween-80、胆酸钠、癸酸钠及油酸钠)、氯化钠及磷脂种类对传递体中1的累积渗透量及皮肤滞留量的影响。其中,采用蛋黄卵磷脂以及Tween-80、胆酸钠、癸酸钠或油酸钠制备的1传递体,24 h累积渗透量分别为(9.37±2.59)、(8.73±1.34)、(6.79±1.83)和(3.46±0.66)mg/cm~2;皮肤滞留量为0.97~1.34mg/cm~2。与1混悬剂组[24 h累积渗透量为0,皮肤滞留量为(0.11±0.06)mg/cm~2]相比,传递体中1的透皮能力和皮肤滞留量显著提高(P0.05);与油酸钠组相比,Tween-80组和胆酸钠组存在显著差异(P0.05)。含Tween-80的传递体中加入氯化钠或用大豆磷脂替换蛋黄卵磷脂后,1的24 h累积渗透量增加至(13.03±4.15)或(10.58±6.98)mg/cm~2,但均没有显著差异(P0.05)。结果显示,以Tween-80及大豆磷脂为材料,不加入氯化钠制备的1传递体z电位为(-38.0±1.5)mV,并显著提高了1的皮肤渗透性及滞留量。
[Abstract]:Quercetin 1) was prepared by high pressure homogenization method. The effects of different surfactants, such as Tween-80, sodium cholate, sodium sebacate, sodium oleate, sodium chloride and phospholipid, on the cumulative permeation and skin retention of 1 in the transporter were investigated by modified Franz diffusion cell method. Among them, the cumulative osmotic capacity of 1 transferer prepared with egg yolk lecithin, Tween-80, sodium cholate, sodium sebacate or sodium oleate for 24 h was 9.37 卤2.59, 8.73 卤1.34, 6.79 卤1.83) and 3.46 卤0.66 mg / cm ~ (-2), and the skin retention was 0.97 卤1.34 mg 路cm ~ (-1) 路m ~ (-2), respectively. Compared with the first suspension group [24 h cumulative osmotic capacity and 0 0. 11 卤0.06)mg/cm~2], the transdermal capacity and skin retention of 1 in the transfer medium increased significantly (P 0. 05), and there was significant difference between the Tween-80 group and the sodium cholate group in comparison with the sodium oleate group (P 0. 05). The 24 h cumulative osmotic capacity of Tween-80 was increased to 13.03 卤4.15% or 10.58 卤6.98 mg / cm ~ (-2) after adding sodium chloride or replacing egg yolk lecithin with soybean phospholipid, but there was no significant difference (P _ (0.05). The results showed that using Tween-80 and soybean phospholipid as materials, the z potential of 1 transferer prepared without sodium chloride was -38.0 卤1.5mV, and the skin permeability and retention of 1 were significantly increased.
【作者单位】：广东药科大学;
【分类号】：R943

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