3种蛇毒类凝血酶制剂在外科手术的止血作用和经济学研究

发布时间：2018-05-06 11:37

本文选题：蛇毒类凝血酶 + 外科手术　；参考：《中国医院药学杂志》2017年17期

【摘要】：目的:探讨3种蛇毒类凝血酶制剂在外科手术的止血有效性,并进行经济学分析,为临床选择最佳止血方案提供依据。方法:回顾性抽取2015年1月-2016年1月在某院骨科腰椎手术及四肢骨折内固定术选用单一止血药注射用白眉蛇毒血凝酶(邦亭)、蛇毒血凝酶注射液(速乐涓)和注射用矛头蛇毒血凝酶(巴曲亭)的手术病例303例进行临床疗效和经济学研究。结果:邦亭、速乐涓和巴曲亭在腰椎手术及四肢骨折内固定术的止血临床有效率分别为76.31%,81.08%,75.00%和72.13%,76.92%,73.33%,两两比较均无统计学差异(P0.05)。不良反应发生率比较,差异性无统计学意义(P0.05)。采用最小成本分析法进行经济学分析,3组患者除蛇毒血凝酶制剂费用和处理不良反应费用外的所有费用基本相等。邦亭组、速乐涓组和巴曲亭组及处理不良反应的费用在腰椎手术及四肢骨折内固定术分别为384.7,451,1 189.1,443,506.1,1 223.4元,两两比较结果显示,邦亭组与速乐涓组比较均无显著性差异(P0.05),巴曲亭组分别与邦亭组与速乐涓组比较均存在显著性差异(P0.05)。结论:注射用白眉蛇毒血凝酶(邦亭)和蛇毒血凝酶注射液(速乐涓)用于腰椎手术及四肢骨折内固定术术中止血的经济性明显优于注射用矛头蛇毒血凝酶(巴曲亭)。
[Abstract]:Objective: to investigate the hemostatic efficacy of three snake venom thrombin preparations in surgical procedures and to provide evidence for clinical selection of the best hemostatic regimen. Methods: from January 2015 to January 2016, hemagglutinase (Bang Ting Pu, snake venom hemagglutinin injection) was used in lumbar vertebra surgery and internal fixation of extremities fracture for single hemostatic injection. A clinical and economic study was carried out in 303 patients treated with hemagglutinin from the venom of the spearhead snake. Results: the hemostasis rates of Bangting, Sulejuan and Baxuting in lumbar vertebrae operation and internal fixation of extremities fracture were 76.31% and 72.13%, respectively, and 72.13%, respectively. There was no significant difference between the two groups (P 0.05). There was no significant difference in the incidence of adverse reactions (P 0.05). The least cost analysis method was used to analyze the three groups of patients with the same cost except snake venom hemagglutinin preparation and the cost of adverse reactions. The cost of treatment of side effects in the Bongting group, Sulejuan group and bactritin group were 384.7451U 1 189.1443506.1 yuan (RMB) in lumbar vertebrae operation and internal fixation of extremities fracture, respectively. The results showed that There was no significant difference between Bongting group and Sulejuan group (P 0.05), but there was significant difference between Baqu Ting group and Bongting group and Sulejuan group (P 0.05). Conclusion: the cost of hemostasis of Baimei snake venom hemagglutinin and snake venom hemagglutinase injection in lumbar vertebrae operation and internal fixation of extremities fracture is better than that of bartrexine injection.
【作者单位】：哈励逊国际和平医院;
【分类号】：R973.1

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