阿司匹林磷脂复合物的制备及其表征

发布时间：2018-05-06 23:35

  本文选题：阿司匹林 + 磷脂复合物　； 参考：《中国药房》2017年25期

【摘要】：目的:制备阿司匹林磷脂复合物(ASP-PC)并进行表征。方法:以ASP与PC的复合率为指标,采用单因素试验筛选ASP-PC的制备方法、PC种类、溶剂种类、反应时间、反应温度、溶剂体积和药脂比,并进行验证。采用紫外分光光度法、热重分析法、X射线衍射法和傅里叶红外光谱分析对所制ASP-PC进行表征。结果:采用磁力搅拌-冷凝回流法,药物-大豆磷脂比为1∶3(mol/mol),溶剂为四氢呋喃(50 m L),58℃下反应3 h,所制ASP-PC的平均复合率为83.52%(RSD=1.16%,n=3)。与ASP、ASP和PC的物理混合物比较,紫外光谱显示ASP-PC没有出现新的吸收峰;热重分析、X射线衍射分析和傅里叶红外光谱分析显示ASP-PC中的ASP与PC发生了相互作用,且ASP-PC在0~300℃范围内质量变化较小。结论:成功制得ASP-PC,其中ASP与PC复合成功,但仍有微量ASP以晶体形式存在。
[Abstract]:Objective: to prepare and characterize aspirin phospholipid complex (ASP-PCC). Methods: single factor test was used to select the preparation method of ASP and PC, such as the type of PC, the kind of solvent, the reaction time, the reaction temperature, the volume of solvent and the ratio of drug to lipid. The ASP-PC was characterized by ultraviolet spectrophotometry, thermogravimetric analysis, X-ray diffraction and Fourier transform infrared spectroscopy. Results: by magnetic agitation-condensation reflux method, the ratio of drug to soybean phospholipid was 1: 3 mol / L, and the solvent was tetrahydrofuran 50 mL / L for 3 h. The average compound rate of ASP-PC was 83.52%. Compared with the physical mixture of ASP-PC and PC, UV spectra showed no new absorption peaks in ASP-PC, and thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) showed that ASP in ASP-PC interacted with PC. The mass change of ASP-PC is small in the range of 0 ~ 300 鈩，

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