一种灵感来源于莲藕的具备药物智能控释特性的3D植入体系的设计与制备

发布时间：2018-05-08 00:16

本文选题：Ag + 抗菌　；参考：《南昌大学》2017年硕士论文

【摘要】：最近几年,3D打印在很多领域引起了人们的关注,例如工程,军事,药学[1]。骨移植材料的定制化制备,被视为是3D打印技术最有前景的应用方向之一[2,3]。到目前为止,每年约有500万人需要进行骨移植手术[4],这其中,无论是常规植入材料或3D打印材料,会有约1.5%-3%的患者会出现术后感染。如果盲目地通过抗生素加以抑制,无疑将给绝大部分无辜的患者造成不必要的负担,并因此产生多种耐药菌株等一系列恶性影响[5],针对这一问题,受莲花根和蜂巢的启发,我们利用3D打印设计出一种管内载药的定制化植入器械,这种器械内所载药物为小尺寸的高性能抗菌纳米材料(Ag),该体系不仅具有智能温敏控释的特性,还可以通过改变内部空腔结构从而改变药物释放曲线。相关的体外实验与动物实验也证明了该项方案的可行性与有效性。这项研究提供了一种高效准确的治疗方案,可有效避免抗生素的滥用,从而显著降低菌株对抗生素产生耐药性的风险。
[Abstract]:In recent years, 3D printing has attracted much attention in many fields, such as engineering, military, pharmacy. The customized preparation of bone graft materials is regarded as one of the most promising applications of 3D printing technology. So far, about 5 million people a year are in need of bone grafts, of which about 1.5 to 3 percent of patients have postoperative infections, whether they are conventional implants or 3D printed materials. If blindly suppressed by antibiotics, it would undoubtedly place an unnecessary burden on the vast majority of innocent patients, and thus produce a series of malignant effects, such as a variety of drug-resistant strains. [5] in response to this problem, inspired by rootlets and hives of lotus flowers, We designed a custom-made implant device for drug loading in tube by using 3D printing. The drugs contained in the device are small and high performance antibacterial nanomaterials, and the system not only has the properties of intelligent temperature sensitive controlled release. The drug release curve can also be changed by changing the internal cavity structure. Related experiments in vitro and animal experiments also proved the feasibility and effectiveness of the scheme. This study provides an efficient and accurate treatment that can effectively avoid the abuse of antibiotics and significantly reduce the risk of antibiotic resistance.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R943

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