菰米血糖生成指数的测定及其改善大鼠胰岛素抵抗的作用

发布时间：2018-05-09 07:51

本文选题：菰米 + 胰岛素抵抗　；参考：《卫生研究》2015年02期

【摘要】：目的了解菰米的血糖生成指数(GI),观察菰米对高脂饲料诱导的胰岛素抵抗(IR)大鼠的作用。方法以50 g葡萄糖为对照,测定健康成人(n=8)食用67 g菰米后2 h内的血糖水平,并根据Wolver方法计算菰米GI。50只雄性SD大鼠随机分成阴性对照组、IR模型组、高剂量菰米组、低剂量菰米组和米面组,喂养8周,测定大鼠空腹血糖(FPG)、空腹胰岛素(INS)、糖化血红蛋白(Hb A1c)和胰高血糖素(GC),计算胰岛素抵抗指数(HOMA-IR)。结果菰米的GI为53.72。IR模型组和米面组大鼠体重、FPG、INS、GC水平和HOMA-IR均高于阴性对照组(P0.05);与IR模型组和米面组相比,高剂量菰米组和低剂量菰米组大鼠体重降低,FPG、INS、GC水平和HOMA-IR均显著下降(P0.05);低剂量菰米组大鼠血清FPG、INS、GC水平略高于阴性对照组和高剂量菰米组,但差异无统计学意义。结论菰米属于低血糖生成指数食物,同时菰米能改善高脂饲料诱导的大鼠胰岛素抵抗,用菰米替代50%的精米面能改善大鼠的胰岛素抵抗状态。
[Abstract]:Objective to understand the glycemic index (GI) of Zizania rice (Zizania rice), and to observe the effect of Zizania rice on insulin resistance (IR) rats induced by high fat diet. Methods the blood glucose level in 2 h after eating 67 g Zizania rice in healthy adults (n=8) was measured with 50 g glucose as the control, and the GI.50 male SD rats were randomly divided into negative control group and IR model according to the Wolver method. Type group, high dose Zizania rice group, low dose Zizania rice group and rice noodle group were fed for 8 weeks. The fasting blood glucose (FPG), fasting insulin (INS), glycosylated hemoglobin (Hb A1c) and glucagon (GC) were measured, and the insulin resistance index (HOMA-IR) was calculated. The results showed that the GI of Zizania rice was the weight of the 53.72.IR model group and the rice group, and the FPG, INS, GC level and HOMA-IR were higher. In the negative control group (P0.05), compared with the IR model group and the rice group, the rats in the high dose Zizania rice group and the low dose Zizania rice group decreased significantly, and the level of FPG, INS, GC and HOMA-IR were significantly decreased (P0.05). The serum FPG, INS, GC levels of the low dose Zizania rice group were slightly higher than those of the negative and high dose Zizania rice groups, but the difference was not statistically significant. Conclusion Zizania rice was not statistically significant. Conclusion Zizania rice was not significant. It is a hypoglycemic index food, while Zizania rice can improve insulin resistance in rats induced by high fat diet. The use of Zizania rice instead of 50% rice noodles can improve the insulin resistance of rats.

【作者单位】：东南大学公共卫生学院营养与食品卫生系;
【基金】：国家自然科学基金(No.81202195,81372986) 教育部博士点基金(No.20120092120063)
【分类号】：R965

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