盐酸氨溴索注射剂超说明书用药的多中心调查研究

发布时间：2018-05-13 13:46

本文选题：氨溴索 + 超说明书用药　；参考：《中国药房》2017年29期

【摘要】：目的:了解盐酸氨溴索注射剂超说明书用药总体情况,为进一步循证评价临床超说明书用药的合理性和规范化管理提供参考。方法:纳入广东省10家医院2014年4月-2015年3月使用盐酸氨溴索注射剂的住院患者的用药医嘱,以药品说明书为标准,统计各类科室用药情况,分析超途径与超剂量用药的发生率,计算各类科室处方日剂量(PDD)和药物利用指数(DUI),评估超剂量用药程度。结果:共纳入使用盐酸氨溴索注射剂的患者761 821人·天,各类科室均存在超说明书用药现象,超说明书用药发生率为62.10%。其中,超途经用药的发生率为40.51%,主要为雾化吸入给药,发生率最高的科室为妇产科(92.70%);超剂量用药的发生率为36.30%,发生率最高的科室为心胸外科(85.36%)。PDD超出说明书规定的有心胸外科、重症监护病房、外科、心血管内科、急诊科、内科和儿科。结论:盐酸氨溴索注射剂超说明书用药现象普遍,有效性、安全性和必要性仍存在争议,需要设计多中心随机对照前瞻试验进行论证。
[Abstract]:Objective: to understand the general situation of ambroxol hydrochloride (Amibroxol) injection overdose medication, and to provide a reference for further evidence-based evaluation of the rationality and standardized management of clinical superscript drug use. Methods: the medical instructions of inpatients who used ambroxol hydrochloride injection from April 2014 to March 2015 in 10 hospitals in Guangdong Province were included. The incidence of superroute and overdose was analyzed, the daily dose of PDD and the drug utilization index were calculated to evaluate the degree of overdose. Results: a total of 761,821 patients were treated with ambroxol hydrochloride injection. Among them, the incidence of overdose was 40.51, which was mainly administered by atomization inhalation, the highest incidence was in gynecology and obstetrics, 92.70% in gynecology and obstetrics, 36.30% in overdose and 85.36% PDD in cardiothoracic surgery. Intensive Care Unit, surgery, Cardiovascular Medicine, Emergency, Internal Medicine and Pediatrics. Conclusion: the overstatement of ambroxol hydrochloride injection is common, effective, safety and necessity are still controversial, it is necessary to design a multicenter randomized controlled prospective trial.
【作者单位】：广东省人民医院/广东省医学科学院药学部;广东药科大学附属第一医院药学部;广州市惠爱医院药学部;深圳市第二人民医院药学部;广州医科大学附属第三医院药学部;深圳市人民医院药学部;广州中医药大学第一附属医院药学部;中山大学附属第一医院药学部;中山大学附属第三医院药剂科;中山大学附属孙逸仙纪念医院药学部;
【基金】：广州市科技计划项目(No.201509010012)
【分类号】：R95

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