聚乙二醇修饰靶向纳米制剂的研究进展

发布时间：2018-05-15 03:33

本文选题：聚乙二醇修饰 + 靶向纳米制剂　；参考：《中国药科大学学报》2017年03期

【摘要】：由于聚乙二醇具有良好的亲水性和柔顺性,能够改善药物的药代动力学和药效学特性,将其修饰到靶向纳米制剂表面能够增加药物在体内的滞留时间和浓度,因此聚乙二醇修饰靶向纳米制剂已成为目前药剂学领域的研究热点。本文总结了靶向纳米制剂的聚乙二醇物理和化学修饰方法,将聚乙二醇-脂质衍生物物理插入纳米制剂,或将聚乙二醇与纳米制剂化学键合;并探讨了聚乙二醇参数(如聚乙二醇相对分子质量、修饰密度、空间构象)对靶向纳米制剂性质的影响,对更好地构建聚乙二醇修饰的靶向纳米制剂提供参考。
[Abstract]:Because of its good hydrophilicity and flexibility, polyethylene glycol can improve the pharmacokinetics and pharmacodynamics of drugs, and the modification of polyethylene glycol onto the surface of targeted nanopharmaceuticals can increase the retention time and concentration of drugs in vivo. Therefore, polyethylene glycol targeted nanopharmaceuticals have become a hot research area in the field of pharmacy. In this paper, the physical and chemical modification methods of polyethylene glycol (PEG) targeting nanopharmaceuticals are summarized. The polyethylene glycol lipids derivatives are physically inserted into the nanoparticles or chemically bonded with the nanoparticles. The effects of polyethylene glycol parameters (such as the relative molecular weight of polyethylene glycol, the density of modification and the space conformation) on the properties of the targeted nanopharmaceuticals were discussed, which provided a reference for the better construction of the targeted nanopharmaceuticals modified by polyethylene glycol.
【作者单位】：中国药科大学药剂学教研室;中国药科大学天然药物活性组分与药效国家重点实验室;
【基金】：国家自然科学基金资助项目(No.81102398,No.81273469) 江苏省自然科学基金资助项目(No.BK2011624) 中央高校基本科研业务费专项基金资助项目(No.JKVD2013011) 国家基础科学人才培养基金资助项目(No.J1030830) 江苏高校优势学科建设工程资助项目~~
【分类号】：R943

【相似文献】