k-卡拉胶在挤出滚圆法制备缬沙坦速释微丸中的应用

发布时间：2018-05-15 04:39

本文选题：缬沙坦 + 速释微丸　；参考：《中国药科大学学报》2015年02期

【摘要】：对挤出滚圆法制备缬沙坦速释微丸的成球促进剂进行筛选,并对缬沙坦速释微丸处方进行优化。通过单因素考察评价并比较微晶纤维素(MCC)、低取代羟丙基纤维素(L-HPC)、交联聚维酮(PVPP)、预胶化淀粉(PCS)及k-卡拉胶5种辅料制得的碳酸钙微丸的质量,初步筛选可用的成球促进剂;进一步评价并比较MCC、L-HPC及k-卡拉胶制得的缬沙坦速释微丸的质量,确定k-卡拉胶为制备缬沙坦速释微丸的最佳成球促进剂。采用Box-Behnken响应面法对该缬沙坦速释微丸的处方进行优化,确定最优处方:k-卡拉胶含量16.98 g,HPMC E5含量2.03 g,SLS含量0.26 g,在此条件下制备出的微丸的收率为91.23%,长径比为1.14,预测值与实际值相符。结果表明k-卡拉胶制得的缬沙坦速释微丸圆整度好、收率高、溶出迅速。
[Abstract]:The rapid release pellets of valsartan were prepared by extrusion and the formulation of valsartan rapid release pellets was optimized. The quality of calcium carbonate pellets prepared from microcrystalline cellulose (MCCO), low substituted hydroxypropyl cellulose (L-HPCN), crosslinked polyvinylidene vinylidene (PVPPN), preglued starch (PCS) and k- carrageenan (k- carrageenan) was evaluated and compared. The quality of valsartan pellets prepared by MCCL-HPC and k- carrageenan was further evaluated and compared, and k- carrageenan was determined as the best spheroidizing promoter for the preparation of valsartan pellets. The formulation of valsartan rapid release pellets was optimized by Box-Behnken response surface method. The optimum formulation was determined as follows: the content of% k- carrageenan was 16.98 g / g of HPMC E5 and the content of 2.03 g / L SLS was 0.26 g. The yield of the pellets was 91.23% and the ratio of length to diameter was 1.14. The predicted value was consistent with the actual value. The results showed that valsartan rapid release pellets prepared by k- carrageenan had good roundness, high yield and rapid dissolution.
【作者单位】：中国药科大学药剂学教研室;南京金陵药业股份有限公司技术中心;
【分类号】：R944

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