长春西汀临床应用的安全性评价及风险管理研究

发布时间：2018-05-15 05:15

本文选题：长春西汀 + 不良反应　；参考：《实用药物与临床》2016年11期

【摘要】：目的通过查阅长春西汀产品说明书内容、不良反应以及配伍禁忌,评价长春西汀的安全性,提出风险管理建议。方法对比国内外长春西汀药品说明书,检索《相关期刊论文》获得有关长春西汀不良反应及配伍禁忌的文献,进行汇总分析。结果国内不同厂家不同剂型长春西汀的说明书存在一定差异,主要是在用法用量、不良反应、注意事项及药物相互作用等方面。检索长春西汀不良反应文献31篇,其中循环系统的AIDR发生率居首位,占33.3%,其次为精神神经系统,占25.9%。检索长春西汀配伍禁忌文献27篇,其与多种药物存在配伍禁忌,且多发生于两种输液续滴过程,比例高达39.53%。注射用长春西汀的溶剂宜选择0.9%氯化钠注射液或5%葡萄糖注射液,在溶剂体积方面,宜选用500 mL溶剂。结论不同专业背景的医务人员对长春西汀安全性和风险防范措施的理解存在差异,有必要向医务人员开展针对性的用药宣传教育,从而保证患者的用药安全。同时建议以原研药品说明书提供的信息为参照,掌握此类药物的安全用药信息,为临床提供完善的药学服务。
[Abstract]:Objective to evaluate the safety and risk management of vinpocetine by consulting the product specification, adverse reactions and compatibility taboos. Methods the literature about vinpocetine adverse reactions and compatibility contraindications were collected and analyzed by comparing the drug specifications of Changchun cetine at home and abroad and searching the full text database of Chinese periodicals. Results the specifications of different dosage forms of vinpocetine in China were different, mainly in usage dosage, adverse reaction, attention and drug interaction. The incidence of AIDR in the circulatory system was the first (33.3%), followed by the mental nervous system (25.9%). A total of 27 contraindications of vinpocetine were searched. There were some contraindications with various drugs, and most of them occurred during the continuous infusion of two kinds of fluids, and the proportion was as high as 39.53. The solvent of vinpocetine for injection should be 0.9% sodium chloride injection or 5% glucose injection, and 500 mL solvent should be used in the volume of solvent. Conclusion there are differences in understanding of the safety and risk prevention measures of vinpocetine among medical staff from different professional backgrounds, so it is necessary to carry out targeted drug use propaganda and education to ensure the safe use of drugs for patients. At the same time, it is suggested that the information provided by the original drug manual should be taken as reference to grasp the safe drug use information of this kind of drug and provide perfect pharmaceutical service for clinical practice.
【作者单位】：宁夏医科大学总医院药剂科;宁夏医科大学总医院临床药理研究室;
【分类号】：R971

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