以聚甲基丙烯酸酯为载体的非pH依赖型速释制剂的研制

发布时间：2018-05-16 06:39

本文选题：速释制剂 + pH　；参考：《中国医药工业杂志》2015年07期

【摘要】：正通过化学修饰(如氨基的季铵化)或加入二羧酸(琥珀酸、戊二酸和己二酸)的方式来改变制剂在溶出时的p H微环境,继而得到布洛芬(IBP)的非p H依赖型速释制剂。采用Eudragit E PO(Eudr E)为载体,通过热熔挤出和注射模塑法制备了直径10 mm、高5 mm的载IBP双凸形片。体外溶出试验表明,即使在季铵化程度最小(25%)的情况下,Eudr E/IBP片的p H依
[Abstract]:The chemically modified (such as quaternary ammonium of amino groups) or the addition of dicarboxylic acid (succinic acid, glutaric acid and adipic acid) are used to change the pH microenvironment of the preparation at the time of dissolution. Using Eudragit E PO(Eudr (E) as the carrier, the IBP double convex sheet with a diameter of 10 mm and a height of 5 mm was prepared by hot melt extrusion and injection molding. Dissolution tests in vitro showed that the pH dependence of Eudr E/IBP tablets was even at the lowest quaternary ammonium level.
【分类号】：R944

【相似文献】