纳米混悬液的制备改良技术研究进展

发布时间：2018-05-16 22:36

本文选题：纳米混悬液 + 下游技术　；参考：《中国药房》2017年10期

【摘要】：目的:为纳米混悬液的进一步研发提供参考。方法:以"纳米混悬液""改良技术""Nanosuspensions""Improved technology"等为关键词,组合查询2008年1月-2016年4月在PubMed、Elsevier、中国知网、万方、维普等数据库中的相关文献,对纳米混悬液的制备改良技术进行综述。结果与结论:共检索到相关文献112篇,其中有效文献27篇。纳米混悬液可增加难溶性药物的饱和溶解度和溶出速率,从而提高药物生物利用度。通过改良纳米混悬液的制备技术,如缩小极限粒径技术、含有纳米晶体的胶囊技术、聚合物包裹技术、提高药物稳定性及安全性等技术,可将其作用进一步提升拓展。进一步缩短制备时间、降低生产成本、提高稳定性、缓控释等将会是此技术的研究方向。
[Abstract]:Objective: to provide reference for further research and development of nanometer suspension. Methods: using "nanometer suspension", "improved technology", "Nanosuspensions" Improved technology "as the key words, combining and querying the relevant literature in the database of PubMeden Elsevier, China Zhiwang, Wanfang, Wiper, etc. from January 2008 to April 2016, the preparation and improvement technology of nano-suspension was reviewed. Results & conclusion: 112 related literatures were retrieved, of which 27 were valid. Nanometer suspension can increase the saturation solubility and dissolution rate of insoluble drugs, and thus improve the bioavailability of drugs. By improving the preparation technology of nano-suspension, such as the technology of reducing the limit particle size, the technology of capsule containing nanocrystalline, the technology of polymer encapsulation, the technology of improving the stability and safety of the drug, the function of the suspensions can be further enhanced and expanded. Further shortening the preparation time, reducing the production cost, improving the stability and slow release will be the research direction of this technology.
【作者单位】：青岛科技大学化工学院制药工程系;青岛市市北区人民医院内二科;
【基金】：山东省自然科学基金资助项目(No.ZR2014HP023)
【分类号】：R943

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