microRNA对药物体内过程调控的研究进展

发布时间：2018-05-19 12:31

本文选题：microRNA + 表观遗传学　；参考：《中国药理学通报》2017年10期

【摘要】：药物的体内过程需经一系列的生物转化和转运途径,依赖于药物代谢酶和转运体的参与。而个体对同一药物的代谢、转运能力存在差异,这一差异不能完全用药物基因组学解释。microRNA作为表观遗传修饰的一个重要方面,是对传统遗传学的强有力补充。人体内多种药物代谢酶和转运体均受到不同的microRNA调控,同一microRNA又可同时调控不同的代谢酶或(和)转运体,二者均提示microRNA极有可能实现较为广泛的宏观调控。该文分别从microRNA对药物代谢酶的调控、对药物转运体的调控以及同时调控代谢酶及转运体的microRNA三个方向综合分析,为研究药物个体差异提出一个极好的切入点,并为合理用药和个体化医疗提供理论基础。
[Abstract]:A series of biotransformation and translocation pathways are required for the in vivo process of drugs, which depend on the involvement of drug metabolizing enzymes and transporters. However, individual metabolism and transport ability of the same drug are different. This difference can not be fully explained by pharmacogenomics. MicroRNA is an important aspect of epigenetic modification, and it is a powerful supplement to traditional genetics. Many drug metabolic enzymes and transporters in human body are regulated by different microRNA, and the same microRNA can regulate different metabolic enzymes or / and transporters at the same time. Both of them suggest that microRNA is likely to achieve a wide range of macro-regulation. In this paper, we analyze the regulation of drug metabolic enzymes by microRNA, the regulation of drug transporters and the regulation of metabolic enzymes and transporters by microRNA, respectively, which provides an excellent starting point for the study of drug individual differences. It also provides theoretical basis for rational drug use and individualized medical treatment.
【作者单位】：中国人民解放军南京总医院药理科;
【分类号】：R96

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