依巴斯汀滴丸剂的制备及溶出度考察

发布时间：2018-05-19 16:35

  本文选题：依巴斯汀 + 滴丸　； 参考：《中国医药工业杂志》2017年08期

【摘要】：用熔融法制备依巴斯汀滴丸,利用Box-Behnken响应面法优化滴丸剂处方与制备工艺,并对预测结果进行验证。结果表明所得模型预测性较好,优化处方工艺为:药物与基质的比例为1∶3.4、基质中聚乙二醇(PEG)4000∶PEG6000的比例为1∶0.41、熔融温度为84℃。采用X射线粉末衍射法(XRD)及差示扫描量热法(DSC)对优化滴丸剂表征,并以市售片剂为对照考察自制滴丸的溶出性能。结果表明,优化后所制得的滴丸剂中药物以非晶态存在;5~30 min滴丸的溶出速度明显高于市售片剂,且滴丸的60 min溶出率为(89.0±4.8)%,片剂则为(78.0±4.7)%。
[Abstract]:Ebastine dropping pills were prepared by melting method. The formulation and preparation process of Ebastine dropping pills were optimized by Box-Behnken response surface method, and the predicted results were verified. The results showed that the prediction of the model was good. The optimized formulation process was as follows: the ratio of drug to matrix was 1: 3.4, the proportion of PEGN 4 000 to PEG6000 in the matrix was 1: 0.41, and the melting temperature was 84 鈩，

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