高蛋白高纤维高脂肪饮食对4种药物在大鼠体内药动学的影响

发布时间：2018-05-20 22:22

本文选题：长期饮食习惯 + 药动学　；参考：《中国医院药学杂志》2017年08期

【摘要】：目的:考察健康大鼠在长期给予不同饮食类型之后对4种药物在体内的药动学影响。方法:SPF级SD大鼠随机分成4组(高蛋白组A、高纤维组B、高脂肪组C、标准饮食组D),分别给予不同饮食类型的食物,进行多种药物(左氧氟沙星、右美沙芬、美托洛尔、二甲双胍)的药动学实验,HPLC-MS/MS分析药物浓度,WinNonlin计算药动学参数,SPSS软件对不同组药动学参数进行统计学分析。结果:右美沙芬和美托洛尔的主要药动学参数C_(max)、AUC_(0-∞)、CL、Vd等组间存在显著性差异(P0.05);二甲双胍和左氧氟沙星的主要药动学参数Cmax、AUC_(0-∞)、CL组间差异无统计学意义(P0.05),其中左氧氟沙星的Vd高脂肪组与其标准组差异具有统计学意义。结论:不同饮食习惯会对药物的药动学产生影响,对不同的药物影响不同,可以成为个体之间药动学差异的一种解释,为后续研究饮食习惯影响药动学的具体因素(如药物的代谢酶、转运体等)提供依据。
[Abstract]:Aim: to investigate the pharmacokinetic effects of different dietary types on the pharmacokinetics of four drugs in healthy rats. Methods Sprague-Dawley rats of SPF grade were randomly divided into 4 groups: high protein group, high fiber group B, high fat group C, standard diet group DX, and various drugs (levofloxacin, dextromethorphan, metoprolol). The pharmacokinetic parameters of metformin were analyzed by HPLC-MS / MS method and the pharmacokinetic parameters were calculated by WinNonlin. SPSS software was used to analyze the pharmacokinetic parameters of different groups. Results: the main pharmacokinetic parameters of dextromethorphan and metoprolol were significantly different between the two groups (P 0.05), while the main pharmacokinetic parameters of metformin and levofloxacin were not significantly different between the two groups (P 0.05). There was a statistically significant difference between the VD high fat group and the standard group of flufloxacin. Conclusion: different dietary habits have different effects on pharmacokinetics of drugs, and different effects on different drugs may be an explanation of pharmacokinetic differences among individuals. To provide basis for further study of specific factors of dietary habits affecting pharmacokinetics (such as metabolic enzymes, transporters, etc.).
【作者单位】：江苏大学附属武进医院消化内科;中南大学药学院;湖南师范大学医学院;
【基金】：江苏省常州市武进区科技发展计划项目(编号:WS201413) 中南大学教师研究基金资助项目(编号:2014JSJJ028)
【分类号】：R965

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