载普伐他汀钠的壳聚糖微球的制备及性能评价

发布时间：2018-05-24 03:39

  本文选题：壳聚糖 + 京尼平　； 参考：《南方医科大学学报》2015年06期

【摘要】：目的制备一种包载普伐他汀钠,以获得长效释放的载药微球。方法以京尼平为交联剂制备载普伐他汀钠的壳聚糖微球,考察壳聚糖相对分子质量、油相水相比、反应温度、搅拌速度等对壳聚糖微球形成的影响,通过扫描电镜观察其微观形貌,测定微球的包封率以及不同p H条件下的溶胀度,并考察了普伐他汀钠的体外累积释药情况。结果载普伐他汀钠药微球体外释放时间长达31 d以上,反应条件不同,药物释放速度不同,普伐他汀的包封率可达54.7%。最佳制备条件为:壳聚糖的粘度为200~400 m Pa.s,油水比10∶1,搅拌速度850 r/min,温度40℃。结论京尼平交联载普伐他汀钠的壳聚糖微球具有较好的长效缓释能力,并且可通过调节交联时间控制其对药物的释放速度。
[Abstract]:Objective to prepare an encapsulated pravastatin sodium for long-term release of drug-loaded microspheres. Methods chitosan microspheres loaded with pravastatin sodium were prepared by using geniapine as crosslinking agent. The effects of relative molecular weight of chitosan, oil phase water ratio, reaction temperature and stirring speed on the formation of chitosan microspheres were investigated. The micromorphology of the microspheres was observed by scanning electron microscope. The entrapment efficiency of the microspheres and the swelling degree under different pH conditions were measured. The cumulative release of pravastatin sodium in vitro was also investigated. Results the release time of pravastatin sodium microspheres in vitro was more than 31 days. The encapsulation efficiency of pravastatin could reach 54.7% with different reaction conditions and different drug release rate. The optimum preparation conditions are as follows: the viscosity of chitosan is 200 ~ 400m Pa. S, the ratio of oil to water is 10: 1, the stirring speed is 850 r / min, the temperature is 40 鈩，

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