大剂量应用维生素C治疗相关疾病安全性的系统评价

发布时间：2018-05-24 14:25

本文选题：大剂量 + 维生素C　；参考：《中国药房》2015年09期

【摘要】：目的:系统评价大剂量应用维生素C治疗相关疾病的安全性,以为临床用药提供循证参考。方法:计算机检索Cochrane图书馆、EMBase、Pub Med、相关期刊论文、万方数据库、中文科技期刊数据库,收集大剂量应用维生素C治疗相关疾病的临床研究,提取资料并评价质量后,采用R语言3.1.1版统计软件对数据进行Meta分析。结果:共纳入23项研究,合计2 069例患者,共发生不良反应540例。Meta分析结果显示,针对有对照组的研究,维生素C治疗组患者总体不良反应发生率与对照组比较差异无统计学意义[RR=1.42,95%CI(0.92,2.20),P=0.382];针对所有纳入研究,维生素C治疗组患者的腹痛发生率为9%[95%CI(0.05,0.14)]、口干发生率为30%[95%CI(0.14,0.54)]、头痛发生率为12%[95%CI(0.06,0.25)]、恶心发生率为25%[95%CI(0.13,0.44)]、腹泻发生率为14%[95%CI(0.07,0.26)]。结论:大剂量应用维生素C治疗相关疾病的安全性较好,但应注意消化系统的不良反应。由于缺乏大样本随机对照试验(RCT)资料,且随访时间较短,该结论尚需要更多大样本、多中心的RCT予以证实。
[Abstract]:Objective: to evaluate the safety of high-dose vitamin C in the treatment of related diseases and provide evidence-based reference for clinical use. Methods: the Cochrane library was searched with Cochrane library, including the full text database of Chinese journal, the database of Wanfang, the database of Chinese sci-tech periodicals, and the clinical research on the treatment of related diseases with high dose of vitamin C, the data were extracted and the quality was evaluated. The data were analyzed by Meta with R language version 3.1.1. Results: a total of 23 studies were included, totally 2 069 patients, 540 cases of adverse reactions. The results of Meta-analysis showed that there was a control group in the study. The overall incidence of adverse reactions in the vitamin C treatment group was not significantly different from that in the control group [RRN 1.42 95%]; The incidence of abdominal pain, dry mouth, headache, nausea and diarrhea were 9%, 30%, 12%, 25% and 14%, respectively. Conclusion: the high dose of vitamin C is safe for the treatment of related diseases, but the adverse reactions of digestive system should be paid attention to. Due to the lack of large sample randomized controlled trial data and the shorter follow-up time, this conclusion needs to be confirmed by multi-center RCT.
【作者单位】：北京市结核病胸部肿瘤研究所;首都医科大学附属北京胸科医院;
【分类号】：R96

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