哺乳期磺胺间甲氧嘧啶暴露对仔鼠行为影响

发布时间：2018-05-26 12:56

本文选题：哺乳期 + 青春期　；参考：《中国公共卫生》2015年04期

【摘要】：目的探讨磺胺间甲氧嘧啶(SMM)哺乳期暴露对青春期小鼠探索和焦虑行为影响。方法小鼠哺乳期以0(对照组)、10、50、200 mg/kg灌胃染毒,连续21 d,断乳后其仔鼠雌、雄分笼正常喂养至49 d,次日进行旷场、黑白巷和高架十字迷宫实验。结果与对照组雄鼠比较,低、中剂量SMM组雄鼠旷场实验中央区域时间[分别为(40.6±10.0)、(41.0±11.9)s]增加,差异有统计学意义(P0.05),中剂量组雄鼠站立次数[(56.5±8.8)次]明显增加,差异有统计学意义(P0.01);与对照组雌鼠比较,低剂量SMM组雌鼠旷场实验中央区域时间[(37.3±9.0)s]增加,差异有统计学意义(P0.05),中剂量SMM组雌鼠的跨越格子数[(159.1±26.0)个]增加,差异有统计学意义(P0.05);高剂量SMM组雌鼠黑白巷实验黑端时间[(57.8±8.2)s]增加,差异有统计学意义(P0.01)。结论哺乳期SMM暴露可干扰仔鼠的探索和焦虑等行为。
[Abstract]:Objective to investigate the effects of sulfamethoxypyrimidine (SMMM) exposure during lactation on exploring and anxiety behavior in pubertal mice. Methods during lactation, mice were fed orally for 21 days at 0 (control group) (control group) for 50 ~ 200 mg/kg. After weaning, the female and male mice were fed to 49 days. The open field, black and white lane and elevated cross maze test were carried out the next day. Results compared with the control group, the central time of open field experiment in the middle dose SMM group was increased [40.6 卤10.0 卤11.9s], the difference was statistically significant (P 0.05), and the standing times of the middle dose SMM group (56.5 卤8.8 times) were significantly increased. Compared with the female rats of the control group, the central area time of the female rats in the low dose SMM group [37.3 卤9.0 s] was increased, the difference was statistically significant (P 0.05), and the cross lattice number of the middle dose SMM group was increased [159.1 卤26.0]. The difference was statistically significant (P 0.05), and the black end time of black and white lane of female rats in high dose SMM group was increased [57.8 卤8.2 s], and the difference was statistically significant (P 0.01). Conclusion SMM exposure during lactation may interfere with the behavior of exploring and anxiety in newborn rats.
【作者单位】：安徽医科大学公共卫生学院营养与食品卫生学系;
【基金】：国家自然科学基金(81202209) 安徽省高等学校优秀青年人才基金(2012SQRL075ZD) 安徽医科大学博士科研基金(0306024101)
【分类号】：R965

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