药师参与抗凝服务对华法林治疗管理的效果评价

发布时间：2018-06-03 18:55

  本文选题：药师 + 抗凝服务　； 参考：《中国药学杂志》2015年06期

【摘要】：目的系统的评价药师参与的抗凝服务对华法林治疗管理的作用。方法计算机检索OVID、SCI、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文期刊数据库(VIP)数据库,万方数据库(WANFANG),纳入药师参与的抗凝服务对华法林治疗管理作用的随机对照试验,检索时间从建库至2014年1月。系统筛选文献、提取资料及评价质量后,采用Rev Man5.0软件进行Meta分析。结果共纳入9个随机对照试验,1 630例患者。Meta分析结果显示,试验组与对照组结局指标:精确的国际标准化比值(international normalized ratio,INR)治疗目标范围时间比、宽松的国际标准化比值治疗目标范围(目标INR±0.2)时间比、全因死亡率、主要出血事件发生率、血栓栓塞事件发生率差异均无统计学意义,效应量依次为MD=1.24,95%CI(-2.83,5.30),P=0.55;MD=2.86,95%CI(-1.52,7.25),P=0.20;RR=0.87,95%CI(0.40,1.91),P=0.73;RR=0.65,95%CI(0.32,1.34),P=0.24;RR=0.85,95%CI(0.40,1.78),P=0.66。而患者满意度指标显示患者对试验组的满意度高于对照组(P≤0.001)。结论基于当前证据,除能增加患者满意度外,药师参与的抗凝服务对华法林治疗管理的其他作用仍有待进一步的研究支持。
[Abstract]:Objective to evaluate the effect of anticoagulant service on warfarin therapy. Methods A computerized search was conducted for OVID-SCI, Chinese Biomedical Literature Database (CBMN), China knowledge Network (CNKI), Weipu Chinese Journal Database (Vip) and Wanfang database (WANFANGG). The results were collected from a randomized controlled trial of the effect of anticoagulant services on the management of warfarin. The retrieval time was from the construction of the database to January 2014. After systematically sifting literature, extracting data and evaluating quality, Meta analysis was carried out with Rev Man5.0 software. Results A total of 1 630 patients were enrolled in 9 randomized controlled trials. The results of Meta-analysis showed that the outcome index of the trial group and the control group: the precise international normalized ratio- INR ratio. There was no significant difference in the treatment target range (target INR 卤0.2) of the looser international standardized ratio (target INR 卤0.2). There was no significant difference in the total mortality rate, the incidence of major haemorrhage events and the incidence of thromboembolism. The order of effect was MD1.2495CI-2.83CI-2.883 ~ (5.30). The patient satisfaction index showed that the patients' satisfaction was higher than that of the control group (P 鈮，

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