2015年某院治疗药物浓度监测结果回顾性分析

发布时间：2018-06-04 16:15

本文选题：治疗药物监测 + 分析　；参考：《中国医院药学杂志》2017年15期

【摘要】：目的:回顾性分析某院患者血药浓度监测数据,探讨血药浓度监测在临床合理用药的作用。方法:对某院2015年9种治疗药物监测数据进行回顾性分析,包括监测品种的构成情况,测定频率情况,监测比例情况以及各个监测品种的监测结果及科室分布情况。结果:该院监测例数和测定频率最多的是免疫抑制剂环孢霉素A,占我院所有监测品种次数的80.3%,其次是甲氨蝶呤和他克莫司。他克莫司、甲氨蝶呤、环孢素A和地高辛监测比例均达到60%以上。90.1%儿科患者的42 h甲氨蝶呤血药浓度分布在0.1~1μmol·L~(-1)。抗癫痫药物中监测次数最多的是丙戊酸,但多数仅监测一次,说明医师和患者对抗癫痫药物的血药浓度的重视程度不够。万古霉素和地高辛用药人群为老年人,建议将血药浓度调整在正常范围的中下限。结论:血药浓度"正常"的构成比较高,说明该院临床医师已充分意识到治疗药物监测的重要性,此外仍需要医师与临床药师密切配合,根据血药浓度监测结果,调整给药方案,有效提高治疗成功率。
[Abstract]:Objective: to retrospectively analyze the monitoring data of blood drug concentration in a hospital, and to explore the role of blood drug concentration monitoring in clinical rational drug use. Methods: retrospective analysis was made on the monitoring data of 9 kinds of therapeutic drugs in a hospital in 2015, including the composition of the monitoring varieties, the determination of frequency, the monitoring ratio, the monitoring results of each monitored variety and the distribution of the departments. Results: the immunosuppressant cyclosporine A was the most frequently monitored in our hospital, accounting for 80.3% of all the monitored varieties, followed by methotrexate and tacrolimus. The blood concentrations of tacrolimus, methotrexate, cyclosporine A and digoxin were above 60%. 90.1% of pediatrics patients. Valproic acid was the most frequently monitored antiepileptic drug, but most of them were monitored only once, which indicated that the concentration of antiepileptic drugs was not paid enough attention to by doctors and patients. Vancomycin and digoxin are aged people. It is suggested that the blood concentration should be adjusted to the middle and lower limit of normal range. Conclusion: the "normal" composition of blood drug concentration is relatively high, which indicates that the clinicians in this hospital have fully realized the importance of therapeutic drug monitoring. In addition, doctors and clinical pharmacists are still required to cooperate closely, according to the results of blood drug concentration monitoring. Adjusts the administration plan, effectively enhances the treatment success rate.
【作者单位】：北京大学人民医院药剂科;
【分类号】：R969.3

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