纳米晶片促进药物经皮渗透作用的研究

发布时间：2018-06-06 00:02

  本文选题：纳米晶片 + 荧光素钠　； 参考：《临床皮肤科杂志》2017年04期

【摘要】：目的 :将纳米晶片用于经皮给药,了解纳米晶片作用于皮肤后,在皮肤表面形成开放给药通道的存在及其闭合,及纳米晶片促进外用药物的经皮渗透作用。方法:(1)扫描电镜观察纳米晶片作用后,在皮肤表面形成孔道的存在和闭合;(2)以0.125%荧光素钠为模型药物,在荧光显微镜下对比观察纳米晶片与荧光素钠结合作用和单纯外用荧光素钠后,荧光在大鼠皮肤的分布情况。结果:(1)纳米晶片可在皮肤表层形成给药通道,该通道在20 min左右即可闭合;(2)经过纳米晶片处理过的大鼠皮肤可见耀眼的荧光(+++);而未经纳米晶片处理的大鼠皮肤仅在角质层可见明显的线状荧光(+),其他部位可见微弱荧光(-)。结论:纳米晶片对外用药物有明显促进渗透作用,纳米晶片在皮肤美容和药物缓控释放领域具有广阔的前景。
[Abstract]:Objective: to use the nanoscale wafers for skin administration to understand the existence and closure of the open delivery channel on the skin surface after the nano wafer is acting on the skin, and the nano wafer to promote the percutaneous penetration of the external drug. Method: (1) the presence and closure of the pores on the skin surface are formed after the scanning electron microscopy (SEM) observation of the nano wafer. (2) 0. 125% fluorescein sodium is a model drug. Under the fluorescence microscope, the distribution of fluorescence in rat skin is observed after the binding of nanoscale to sodium fluorescein and sodium fluorescein sodium. Results: (1) the nanoscale can form the drug channel on the surface of the skin, and the channel can be closed at about 20 min. (2) the nanoscale wafer is treated with a nanoscale wafer. The skin of rats showed bright fluorescent (+ + +), while the skin of rats without nanoscale treatment was only visible linear fluorescence (+) in the cuticle layer and weak fluorescence in other parts. Conclusion: the nano wafers can obviously promote osmosis, and the nanocrystalline tablets have a broad front in the field of skin beauty and drug release. View.
【作者单位】： 中国人民解放军第二0二医院;
【分类号】：R943
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本文编号：1984015