超多孔水凝胶体系的溶胀和溶蚀动力学研究

发布时间：2018-06-08 08:02

本文选题：魔芋葡甘聚糖 + 超多孔水凝胶　；参考：《中成药》2015年02期

【摘要】：目的考察含魔芋葡甘聚糖的超多孔水凝胶复合物在介质中溶胀和溶蚀动力学特点及其影响因素。方法采用泡沫聚合法制备超多孔水凝胶和加入魔芋葡甘聚糖的超多孔水凝胶,测定它们在介质p H、酶、Na Cl和葡萄糖作用下体系溶胀比和随时间变化的溶蚀率。结果魔芋葡甘聚糖-超多孔水凝胶复合物在蒸馏水中溶胀和溶蚀均最快,3 min溶胀比为161.3,48 h溶蚀率为85.6%,而超多孔水凝胶达到溶胀平衡较慢;魔芋葡甘聚糖-超多孔水凝胶复合物在含Na Cl或葡萄糖介质中溶胀和溶蚀减弱,其中Na Cl的影响比葡萄糖显著;与不含酶的介质(不同p H)相比,酶的存在加快了魔芋葡甘聚糖-超多孔水凝胶复合物体系的溶蚀。结论魔芋葡甘聚糖加入后所形成的超多孔水凝胶复合物体系溶胀性能较优而溶蚀延缓,但介质p H、酶、盐和糖等因素会影响体系溶胀和溶蚀行为。
[Abstract]:Aim to investigate the swelling and dissolution kinetics of hyperporous hydrogel complex containing konjac glucomannan and its influencing factors. Methods the ultraporous hydrogels and the superporous hydrogels with konjac glucomannan were prepared by foam polymerization. The swelling ratio and corrosion rate of the superporous hydrogels with medium pH, enzyme Na Cl and glucose were measured. Results the swelling ratio of konjac glucomannan and super porous hydrogel in distilled water was 161.3n 48 h, the swelling ratio was 161.3n 48 h, but the swelling equilibrium of super-porous hydrogel was slower. The swelling and corrosion of konjac glucomannan superporous hydrogels decreased in NaCl or glucose medium, and the effect of NaCl was more significant than that of glucose. The presence of enzyme accelerates the dissolution of konjac glucomannan-superporous hydrogel complex system. Conclusion the swelling property of the superporous hydrogel complex formed by konjac glucomannan is better and the dissolution is delayed. However, the swelling and corrosion behavior of the system is affected by the factors such as pH, enzyme, salt and sugar.
【作者单位】：宁夏医科大学总医院;宁夏医科大学药学院;宁夏回药现代化工程技术研究中心;回医药现代化省部共建教育部重点实验室;
【基金】：2009年国家自然科学基金项目(30902010)
【分类号】：R943

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