细胞膜修饰的纳米粒载药系统的研究进展

发布时间：2018-06-10 07:13

本文选题：细胞膜修饰 + 纳米粒　；参考：《中国医药工业杂志》2017年01期

【摘要】：近年来,以纳米粒为载体的递药系统研究取得了较大进展,然而纳米粒在体内会产生免疫原性和纳米毒性。因此,细胞膜作为一种更安全有效的载体已成为药物传递领域的研究热点。将细胞膜与纳米粒进行结合,不仅能增加纳米粒的生物相容性,还可以通过选择不同种类细胞膜,如血细胞、干细胞或细菌细胞等,使纳米粒获得靶向性、不易被免疫系统识别且能延长体循环时间等多种生物学特性。本文介绍了具有生物伪装功能的细胞膜修饰纳米粒的制备方法、特性和应用,以期促进纳米粒在药物传递领域的应用。
[Abstract]:In recent years, great progress has been made in the research of drug delivery system based on nanoparticles. However, nanoparticles can produce immunogenicity and nano-toxicity in vivo. Therefore, cell membrane as a safer and more effective carrier has become a research hotspot in the field of drug delivery. The combination of cell membrane and nanoparticles not only increases the biocompatibility of nanoparticles, but also enables the nanoparticles to be targeted by selecting different types of cell membranes, such as blood cells, stem cells or bacterial cells. It is difficult to be recognized by the immune system and can prolong the body circulation time and other biological characteristics. The preparation, characteristics and application of membrane modified nanoparticles with biological camouflage were introduced in this paper, in order to promote the application of nanoparticles in the field of drug delivery.
【作者单位】：南京工业大学药学院;南京百思福医药科技有限公司;
【分类号】：R943

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