bFGF在长春瑞滨致兔组织损伤后不同时间实施干预的效果

发布时间：2018-06-12 02:16

本文选题：碱性成纤维细胞生长因子 + 长春瑞滨　；参考：《中国老年学杂志》2015年23期

【摘要】：目的探讨碱性成纤维细胞生长因子(b FGF)在长春瑞滨外渗家兔组织不同时间干预的效果。方法建立54只长春瑞滨外渗的家兔模型,分别在建模后30 min、24 h、72 h开始实施b FGF湿敷、硫酸镁湿敷及不干预,通过肉眼及光镜观察上述各组干预后3、5、8、11、14、22 d的皮肤组织损伤程度。结果长春瑞滨外渗后30 min、24 h干预后,b FGF组皮损评分及病理损伤评分均显著低于硫酸镁组及对照组(P0.05);外渗后72 h干预时,b FGF组皮损评分及病理损伤评分均显著低于对照组(P0.05);硫酸镁组仅于外渗后72 h干预时病理损伤评分低于对照组(P0.05)。结论长春瑞滨外渗时采用b FGF湿敷能减轻组织损伤,尤以外渗后30 min开始干预效果显著。
[Abstract]:Objective to investigate the effect of basic fibroblast growth factor (bFGF) intervention in rabbits with vinorelbine exosmosis at different time. Methods 54 rabbit models of vinorelbine exosmosis were established, and bFGF wet compress, magnesium sulfate wet compress and no intervention were performed at 30 min and 24 h, respectively. The injury degree of skin tissue was observed by naked eye and light microscope. Results the skin lesion score and pathological injury score in the bFGF group were significantly lower than those in the magnesium sulfate group and the control group after 24 h intervention at 30 min and 24 h after vinorelbine exosmosis, and were significantly lower in the bFGF group than in the control group at 72 h after exosmosis, and the skin lesion score and pathological injury score in the bFGF group were significantly lower than those in the control group. The pathological injury score of magnesium sulfate group was lower than that of control group at 72 h after exosmosis. Conclusion the application of bFGF wet compress in vinorelbine exosmosis can reduce tissue injury, especially 30 min after external osmosis.
【作者单位】：金华职业技术学院医学院;金华市实验动物中心;浙江大学金华医院手术室;温州医科大学护理学院;
【基金】：浙江省科技厅实验动物科技计划项目(No.2013C37023)
【分类号】：R965

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