非诺贝特-淀粉源介孔碳载体固体分散体双层渗透泵控释片的研究

发布时间：2018-06-13 00:33

  本文选题：淀粉源介孔碳载体 + 难溶性药物　； 参考：《中国药学杂志》2017年16期

【摘要】：目的用淀粉源介孔碳(SMC)作为载体来提高非诺贝特(FNB)的溶出速率,并结合双层渗透泵技术使药物得到控释释放,从而提高口服生物利用度。方法通过吸附法将药物FNB载入SMC的介孔孔道中制备载药体系(FNB-SMC)。通过差示扫描量热法(DSC)和粉末X射线衍射法(PXDR)对载药前后药物的存在状态进行表征。体外溶出实验考察FNB-SMC的溶出速率,并对双层渗透泵片进行优化。通过体内实验考察自制片的口服生物利用度。结果表征结果表明,FNB以无定型状态存在在SMC的介孔孔道中。体外溶出实验表明,SMC能显著提高FNB的溶出速率,并且双层渗透泵技术使药物达零级释放。体内实验表明,自制片的口服生物利用度得到明显改善。结论淀粉源介孔碳载体和双层渗透泵技术的联合防止了突释效应,明显改善FNB的口服吸收。
[Abstract]:Objective to improve the dissolution rate of fenofibrate (FNB) by using starch source Kong Tan (SMC) as a carrier, and combine the double osmotic pump technology to release the drug by controlled release, thus improving the oral bioavailability. The drug FNB was loaded into the mesoporous channel of SMC by adsorption method (FNB-SMC). Differential scanning calorimetry (DSC) was used. X ray diffraction (PXDR) was used to characterize the existing state of the drug before and after the drug loading. The dissolution rate of FNB-SMC was investigated in vitro and the double layer osmotic pump was optimized. The oral bioavailability of the homemade tablets was investigated by the experiment in vivo. The results showed that the FNB was in the mesoporous channel of SMC in the amorphous state. The dissolution test in vitro showed that SMC could significantly improve the dissolution rate of FNB, and the double layer osmotic pump technology made the drug release to zero. In vivo experiments showed that the oral bioavailability of the homemade tablets was obviously improved. Conclusion the combination of the starch source Kong Tan carrier and the double layer osmotic pump prevented the sudden release effect and obviously improved the oral absorption of FNB. Accept.
【作者单位】： 锦州医科大学;
【基金】：校长基金-奥鸿博泽基金-医药创新专项资助(XZJJ20130104-07)
【分类号】：R943
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本文编号：2011790