不同剂量单唾液酸四己糖神经节苷脂钠的临床评估研究

发布时间：2018-06-14 16:08

本文选题：GM1 + 单唾液四已糖神经节苷酯钠　；参考：《重庆理工大学》2017年硕士论文

【摘要】：目的:观察不同剂量单唾液四已糖神经节苷酯钠治疗脑出血、急性脑梗死、糖尿病周围神经、脑出血的临床疗效及不良反应发生率,进行对比以评估其治疗的有效性与安全性,为标准的治疗方案的制订提供科学依据。方法:回顾性研究我院2013年03月~2015年03月期间收治的颅脑损伤、急性脑出血、急性脑梗死、糖尿病外周神经病变病例。根据高、中、低三种不同剂量单唾液四已糖神经节苷酯钠进行治疗,观察病例治疗前后临床疗效及其不良反应。结果:1.四组试验脑损伤患者在接受治疗一周的治疗期后,患者在对照组70例恢复良好,中残11例,10例重度残疾,植物生存26例,总有效率77.77%。高剂量治疗组98例恢复良好,中残7例,其中8例重度残疾,植物状态4例,总有效率为96.58%。中剂量治疗的患者94例恢复良好,其中9例中度残疾,9例重度残疾,植物生存5例,总有效率为95.72%。低剂量治疗组85例恢复良好,中残10例,9例重度残疾人,植物生存13例,总有效率为88.88%。由此可以看出,治疗组的总效率比总有效剂量和治疗效果和正相关显著高,差异有统计学意义(P0.05)。四组治疗后,比较四组治疗颅内压、收缩压和舒张压,差异无统计学意义(P0.05)。2.四组患者急性脑出血指标进行比较,具有统计学显著差异(P0.05)。3.急性脑梗死组的治疗前,没有显著差异(P0.05),统计治疗组和对照组NIHSS评分和Barthel指数得分,治疗后,有显著差异意义(P0.05),四组NIHSS评分和Barthel指数评分在治疗前后较对照组显著高于治疗组,在NIHSS评分和Barthel指数评分之间差值具有统计学差异(P0.05)。4.糖尿病周围神经病变对照组为76.92%,前高后低剂量治疗组中分别为84%,80%,总有效率,显著高出组之间的差异(P0.05),统计学差异显著。结论:单唾液四已糖神经节苷酯钠对于改善急性脑出血、急性脑梗死、颅脑损伤、糖尿病外周神经病变有效,治疗过程中高、中、低三种剂量造成不良反应轻微,其治疗效果随着用药剂量的增加而增加,不良反应率也随着用药剂量的增加而增加,呈现正相关趋势。由于本次实验病例研究对象较少,且存在一些不足,因此本次实验研究结果存在一定的不确定性,这些结论还有待大量随机实验数据进一步研究证实。
[Abstract]:Objective: to observe the clinical efficacy and incidence of adverse reactions in the treatment of intracerebral hemorrhage, acute cerebral infarction, diabetic peripheral nerve and intracerebral hemorrhage with different doses of single saliva tetrahexosylganglioside sodium, and to evaluate the efficacy and safety of the treatment. To provide scientific basis for the formulation of standard treatment program. Methods: the patients with craniocerebral injury, acute cerebral hemorrhage, acute cerebral infarction and diabetic peripheral neuropathy were retrospectively studied. According to three different doses of high, middle and low doses of single saliva tetrahexosylganglioside sodium, the clinical efficacy and adverse reactions were observed before and after treatment. The result is 1: 1. After one week of treatment, 70 patients in the control group recovered well, 11 patients with moderate disability and 10 patients with severe disability and 26 patients with vegetative survival. The total effective rate was 77.77g. In the high dose group, 98 cases recovered well, 7 cases were moderately disabled, 8 cases were severely disabled, 4 cases were vegetative state, the total effective rate was 96.58%. 94 cases of moderate dose therapy recovered well, 9 cases of moderate disability 9 cases of severe disability, 5 cases of vegetative survival, the total effective rate was 95.72%. In the low dose group, 85 cases recovered well, 10 cases with moderate disability, 9 cases with severe disability, 13 cases with vegetative survival, the total effective rate was 88.88%. It can be seen that the total efficiency of the treatment group is significantly higher than that of the total effective dose and the therapeutic effect, and the difference is statistically significant (P 0.05). After treatment, the four groups were compared in intracranial pressure, systolic blood pressure and diastolic blood pressure, the difference was not statistically significant (P 0.05). 2. The indexes of acute intracerebral hemorrhage in the four groups were significantly different (P < 0.05). There was no significant difference before treatment in acute cerebral infarction group (P 0.05). NIHSS score and Barthel index score in statistical treatment group and control group were significantly different after treatment. NIHSS score and Barthel index score in four groups were significantly higher than those in control group before and after treatment. The difference between NIHSS score and Barthel Index score was statistically significant (P < 0.05). The total effective rate of diabetic peripheral neuropathy in the control group was 76.92 and that in the former high and low dose group was 840.The total effective rate was significantly higher than that between the two groups (P 0.05). Conclusion: single saliva tetrahexosylganglioside sodium is effective in improving acute cerebral hemorrhage, acute cerebral infarction, craniocerebral injury and diabetic peripheral neuropathy. The therapeutic effect increased with the increase of dosage, and the rate of adverse reaction increased with the increase of dosage, showing a positive correlation trend. Due to the small number of experimental cases and some shortcomings, there is some uncertainty in the results of this experiment. These conclusions need to be confirmed by a large number of random experimental data.
【学位授予单位】：重庆理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R971

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