微乳法制备姜黄素固体脂质纳米粒

发布时间：2018-06-15 01:22

  本文选题：姜黄素 + 微乳法　； 参考：《中国药房》2015年19期

【摘要】：目的:制备姜黄素固体脂质纳米粒。方法:微乳法制备姜黄素固体脂质纳米粒。采用伪三元相图法优选微乳三相因素,确定优化条件后,将热微乳分散于冷水中制备固体脂质纳米粒。单因素试验初筛各因素(乳化剂、脂质材料、脂质用量、药脂比、冷水相温度和微乳保温温度)后,以包封率为指标进行正交试验优化处方,并进行验证试验。结果:65℃下由硬脂酸(油相)、聚山梨酯80(乳化剂)、乙醇(助乳化剂)组成三相,乳化剂与助乳化剂比为1∶4所制得的微乳最佳。固体脂质纳米粒的优化处方为姜黄素投药量为50 mg、硬脂酸的用量为0.5 g、冷水相温度为2℃、微乳保温温度为65℃;所得固体脂质纳米粒的包封率为87.73%、载药量为7.72%、粒径为(156.9±2.2)nm、多分散系数为0.480,平均Zeta电位为-24.8 m V(RSD2%,n=3)。结论:采用微乳法制备固体脂质纳米粒操作简便、可行。
[Abstract]:Objective: to prepare curcumin solid lipid nanoparticles. Methods: curcumin solid lipid nanoparticles were prepared by microemulsion method. Three phase factors of microemulsion were selected by pseudo-ternary phase diagram method. After determining the optimum conditions, the thermal microemulsion was dispersed in cold water to prepare solid lipid nanoparticles. After screening the factors (emulsifier, lipid material, lipid dosage, ratio of drug to lipid, cold water phase temperature and microemulsion holding temperature), the encapsulation efficiency was optimized by orthogonal test and the validation test was carried out. Results the microemulsion was composed of stearic acid (oil phase), polysorbate 80 (emulsifier) and ethanol (co-emulsifier) at 65 鈩，

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