9个企业复方地巴唑氢氯噻嗪胶囊壳中8种金属元素的含量分析

发布时间：2018-06-15 23:37

本文选题：电感耦合等离子体质谱法 + 复方地巴唑氢氯噻嗪胶囊　；参考：《中国药房》2015年01期

【摘要】：目的:建立同时测定胶囊壳中8种金属元素(Cu、Cr、Co、Ni、As、Ag、Cd、Pb)含量的方法,并分析9个企业复方地巴唑氢氯噻嗪胶囊壳中的8种金属元素的含量。方法:采用电感耦合等离子体质谱(ICP-MS)法。样品加硝酸10 ml在150℃预消解2 h,再经微波消解处理后,分析9个企业21批胶囊壳中8种金属元素的含量。结果:8种金属元素检测质量浓度线性范围均为1~200ng/ml(r=0.999 8~1.000 0);平均回收率为94%~105%,RSD均≤4.0%(n=6)。9个企业样品中8种金属元素均有检出,其中多数企业样品Cu、Cr和Pb含量较高但未超过标准要求,但有1个企业样品Cr含量严重超标。结论:建立的含量分析方法简单、快速、准确;建议各企业应对所用胶囊进行严格的质量控制。
[Abstract]:Objective: to establish a method for simultaneous determination of 8 metal elements (Cu, Cr, Co, Ni, As, Ag, Cd, Pb) in capsule shells and to analyze the content of 8 metal elements in the 9 Compound Bendazol and Hydrochlorothiazide Capsules shells. Method: inductively coupled plasma mass spectrometry (ICP-MS). The sample and 10 ml were pre digestion 2 h at 150 degrees, and then microwave digestion. After the analysis, the content of 8 metal elements in 21 batches of capsule shells of 9 enterprises was analyzed. Results: the linear range of mass concentration of 8 metal elements was 1~200ng/ml (r=0.999 8~1.000 0); the average recovery rate was 94%~105%, RSD equal to 4% (n=6).9 of the enterprise samples were detected by 8 metal elements, and most of the enterprise samples Cu, Cr and Pb content was higher. No more than the standard requirements, but 1 enterprise samples Cr content is seriously exceeding the standard. Conclusion: the analysis method established is simple, fast and accurate. It is suggested that all enterprises should carry out strict quality control for the capsules used.
【作者单位】：福建医科大学附属第一医院药学部;福建省药品检验所;福建医科大学省立临床学院;福建省立医院药学部;
【分类号】：R927.2;O657.63

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