经典抗菌药氯碘羟喹抗癌机制的研究进展

发布时间：2018-06-16 17:14

本文选题：氯碘羟喹 + 癌细胞　；参考：《中国新药杂志》2015年09期

【摘要】：氯碘羟喹从1934年开始作为一种口服抗菌药广泛应用于胃肠道感染性疾病,后来因为发现其能诱发亚急性脊髓视神经病而被限制使用。2005年开始,陆续有研究报道,氯碘羟喹具有诱导癌细胞凋亡的作用,随后针对氯碘羟喹抗癌作用机制的一系列研究逐渐开展,并证实其能作为铜、锌等金属离子载体,通过多种细胞通路诱导癌细胞的凋亡,因此氯碘羟喹抗癌作用的研究得到重视。本文就氯碘羟喹抗癌机制的研究进展做一综述。
[Abstract]:Chloroiodoquine has been widely used as an oral antimicrobial agent in gastrointestinal infectious diseases since 1934, but has been restricted for its ability to induce subacute spinal optic neuropathy. Chloroiodoquine can induce apoptosis of cancer cells. Subsequently, a series of studies on the anticancer mechanism of chloroiodoquine have been carried out, and it has been proved that chloroiodoquine can be used as a carrier of copper, zinc and other metal ions to induce apoptosis of cancer cells through various cell pathways. Therefore, the study of antitumor effect of chloroiodoquine has been paid more attention. In this paper, the research progress of antitumor mechanism of chloroiodoquine is reviewed.
【作者单位】：中山大学孙逸仙纪念医院神经外科;中山大学药学院药理学与毒理学实验室;
【基金】：国家自然科学基金(31371070) 广东省自然科学基金(S2011010002638) 广东省科技计划项目(2012B031800356)
【分类号】：R96

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