抗胆碱药盐酸戊乙奎醚减慢心率及影响心率变异性的初步观察

发布时间：2018-06-18 12:16

本文选题：盐酸戊乙奎醚 + 心率变异性　；参考：《中国新药杂志》2015年22期

【摘要】：目的:观察抗胆碱药盐酸戊乙奎醚(penehyclidine hydrochloride,PH)对健康受试者心率及心率变异性的作用,初步探讨其对自主神经活动的影响。方法:健康受试者26例,男女各半,年龄20~30岁,随机分为0.3,0.4,0.6,0.8和1.0 mg PH组,单次给药。每个剂量组随机选择2例(男女各1例)受试者行24 h动态心电图监测,采集健康受试者给药前后24 h的平均心率及心率变异性时域参数(SDNN,SDNN Idx,r MSSD,SDANN,p NN50,TI);其余16例受试者采用常规心电图监测记录给药前后24 h心率。比较给药前后24 h心率,并采用心率变异性(heart rate variability,HRV)时域分析法考察心率变异性的变化。结果:PH给药后,常规心电图显示受试者心率明显减慢(P0.05);动态心电图监测结果表明受试者24 h平均心率与给药前相比显著减慢(P0.01),1 h SDNN显著提升(P0.01),24 h长程SDNN,SDNN Idx,r MSSD,p NN50和TI水平较给药前呈上升趋势;SDANN水平略低于给药前。结论:PH可能通过非M2受体或增强迷走神经张力影响HRV,进而减慢心率。
[Abstract]:Objective: To observe the effect of anticholinergic penehyclidine hydrochloride (PH) on heart rate and heart rate variability of healthy subjects and to explore its effect on autonomic nervous activity. Methods: 26 healthy subjects were divided into 0.3,0.4,0.6,0.8 and 1 mg PH groups at random, each dose, each dose, each dose. The subjects were randomly selected 2 cases (1 men and women) with 24 h dynamic electrocardiogram monitoring. The average heart rate and heart rate variability time domain parameters (SDNN, SDNN Idx, R MSSD, SDANN, P NN50, TI) were collected by healthy subjects before and after administration (SDNN Idx, R MSSD, SDANN, P NN50, TI). The other 16 subjects were monitored before and after the routine ECG monitoring of 24 h heart rate before and after the drug administration, and 24 heart rate before and after the administration were compared. The change of heart rate variability was investigated by time domain analysis of heart rate variability (heart rate variability, HRV). Results: after PH administration, the routine ECG showed that the heart rate of the subjects was significantly slower (P0.05). The results of dynamic ECG monitoring showed that the average heart rate of the subjects was significantly slower than that of the 24 h (P0.01), and the 1 h SDNN significantly increased (P0.01), 24 H long range SDNN, SDNN Idx, R MSSD, P NN50 and TI showed an upward trend before drug delivery; SDANN level was slightly lower than before administration. Conclusion: PH may be influenced by non M2 receptors or enhanced vagal tension and then slowing down the heart rate.
【作者单位】：中国人民解放军成都军区总医院;
【分类号】：R969

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